Search Results
Overview
| Uniprot ID | Q9CZW5 |
|---|---|
| Protein Name | Mitochondrial import receptor subunit TOM70 |
| Gene Name | Tomm70 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 362 | LDKVISLKEANVKLR |
Function
Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (By similarity). Mediates TBK1 and IRF3 activation induced by MAVS in response to virus infection and promotes host antiviral responses during virus infection (PubMed:20628368)
Protein Sequence
10
MAASKPIEAA
20
MAAAAAPGSG
30
NGVGGGGGTA
40
GPGSGAGTLP
50
RWHVALAIGA
60
PLLLGAGAMY
70
LWSRRRRRRE
80
AGGRGDASGL
90
KRNSERKTPE
100
GRASPALGSG
110
HHDGSGDSLE
120
MSSLDRAQAA
130
KNKGNKYFKA
140
GKYEQAIQCY
150
TEAISLCPTE
160
KNVDLSTFYQ
170
NRAAAFEQLQ
180
KWKEVAQDCT
190
KAVELNPKYV
200
KALFRRAKAH
210
EKLDNKKECL
220
EDVTAVCILE
230
GFQNEQSMLL
240
ADKVLKLLGK
250
ENAKEKYKNR
260
EPLMPSPQFI
270
KSYFSSFTDD
280
IISQPMLKGE
290
KSDEDKDKEG
300
EALEVKENSG
310
YLKAKQYMEE
320
ENYDKIISEC
330
SKEIDAQGKY
340
MAEALLLRAT
350
FYLLIGSANA
360
AKPDLDKVIS
370
LKEANVKLRA
380
NALIKRGTMC
390
MQQQQPMLST
400
QDFNMAAEID
410
PMNSDVYHHR
420
GQLKILLDLV
430
EEAVADFDAC
440
IRLRPKFALA
450
QAQKCFALYR
460
QAYTANNSSQ
470
VQAAMKGFEE
480
IIKKFPRCAE
490
GYALYAQALT
500
DQQQFGKADE
510
MYDKCIDLEP
520
DNATTYVHKG
530
LLQLQWKQDL
540
DKGLELISKA
550
IEIDNKCDFA
560
YETMGTIEVQ
570
RGNMEKAIDM
580
FNKAINLAKS
590
EMEMAHLYSL
600
CDAAHAQTEV
610
AKKYGLKPPT
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Molecular Function | GO:0030943 | mitochondrion targeting sequence binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0002218 | activation of innate immune response |
| Biological Process | GO:0098586 | cellular response to virus |
| Biological Process | GO:0061052 | negative regulation of cell growth involved in cardiac muscle cell development |
| Biological Process | GO:0002230 | positive regulation of defense response to virus by host |
| Biological Process | GO:0032728 | positive regulation of interferon-beta production |
| Biological Process | GO:1903955 | positive regulation of protein targeting to mitochondrion |
| Biological Process | GO:0030150 | protein import into mitochondrial matrix |
| Biological Process | GO:0045039 | protein insertion into mitochondrial inner membrane |
| Biological Process | GO:0006626 | protein targeting to mitochondrion |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0097068 | response to thyroxine |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.