Search Results

Overview

Uniprot ID	Q9D023
Protein Name	Mitochondrial pyruvate carrier 2
Gene Name	Mpc2
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
19	TYHRLMDKVELLLPK
26	KVELLLPKKLRPLYN
27	VELLLPKKLRPLYNH

Function

Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (PubMed:22628554). Plays an essential role in cellular metabolism (By similarity)

Protein Sequence

10 MAAAGARGLR 20 ATYHRLMDKV 30 ELLLPKKLRP 40 LYNHPAGPRT 50 VFFWAPIMKW 60 GLVCAGLADM 70 ARPAEKLSTA 80 QSTVLMATGF 90 IWSRYSLVII 100 PKNWSLFAVN 110 FFVGSAGASQ 120 LFRIWRYNQE LKSKGIQ

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0050833	pyruvate transmembrane transporter activity
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process	GO:0006086	pyruvate decarboxylation to acetyl-CoA
Biological Process	GO:0006850	pyruvate import into mitochondria
Cellular Component	GO:0098800	inner mitochondrial membrane protein complex
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:7770001	mitochondrial pyruvate carrier complex
Cellular Component	GO:0005739	mitochondrion

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.