Search Results
Overview
| Uniprot ID | Q9D0E1 |
|---|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein M |
| Gene Name | Hnrnpm |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 387 | KRGEIIAKQGGGGAG |
Function
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines (By similarity)
Protein Sequence
10
MAAGVEAAAE
20
VAATEPKMEE
30
ESGAPCVPSG
40
NGAPGPKGEE
50
RPTQNEKRKE
60
KNIKRGGNRF
70
EPYSNPTKRY
80
RAFITNIPFD
90
VKWQSLKDLV
100
KEKVGEVTYV
110
ELLMDAEGKS
120
RGCAVVEFKM
130
EESMKKAAEV
140
LNKHSLSGRP
150
LKVKEDPDGE
160
HARRAMQKVM
170
ATTGGMGMGP
180
GGPGMINIPP
190
SILNNPNIPN
200
EIIHALQAGR
210
LGSTVFVANL
220
DYKVGWKKLK
230
EVFSMAGVVV
240
RADILEDKDG
250
KSRGIGIVTF
260
EQSIEAVQAI
270
SMFNGQLLFD
280
RPMHVKMDER
290
ALPKGDFFPP
300
ERPQQLPHGL
310
GGIGMGLGPG
320
GQPIDANHLS
330
KGIGMGNLGP
340
AGMGMEGIGF
350
GINKIGGMEG
360
PFGGGMENMG
370
RFGSGMNMGR
380
INEILSNALK
390
RGEIIAKQGG
400
GGAGGSVPGI
410
ERMGPGIDRI
420
SGAGMERMGA
430
GLGHGMDRVG
440
SEIERMGLVM
450
DRMGSVERMG
460
SSIERMGPLG
470
LDHMASSIER
480
MGQTMERIGS
490
GVERMGAGMG
500
FGLERMAAPI
510
DRVGQTIERM
520
GSGVERMGPA
530
IERMGLSMDR
540
MVPTGMGASL
550
ERMGPVMDRM
560
ATGLERMGAN
570
NLERMGLERM
580
GANSLERMGL
590
ERMGANSLER
600
MGPAMGPALG
610
AGIERMGLAM
620
GGAGGASFDR
630
AIEMERGNFG
640
GSFAGSFGGA
650
GGHAPGVARK
660
ACQIFVRNLP
670
FDFTWKMLKD
680
KFNECGHVLY
690
ADIKMENGKS
700
KGCGVVKFES
710
PEVAERACRM
720
MNGMKLSGRE
IDVRIDRNA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0042382 | paraspeckles |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:1990405 | protein antigen binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Biological Process | GO:0000380 | alternative mRNA splicing, via spliceosome |
| Biological Process | GO:1904591 | positive regulation of protein import |
| Biological Process | GO:1900182 | positive regulation of protein localization to nucleus |
| Biological Process | GO:0099175 | regulation of postsynapse organization |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.