Search Results

Overview

Uniprot IDQ9D0K2
Protein NameSuccinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Gene NameOxct1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
176 GSPIKYNKDGSVAIA
185 GSVAIASKPREVREF
296 DGKGKSGKPGGDVRE
418 ANWMIPGKMVKGMGG
421 MIPGKMVKGMGGAMD
434 MDLVSSSKTKVVVTM
436 LVSSSKTKVVVTMEH
446 VTMEHSAKGNAHKIM
455 NAHKIMEKCTLPLTG
463 CTLPLTGKQCVNRII
473 VNRIITEKGVFDVDK

Function

Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (By similarity). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor (3-oxo acid) carboxylate and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)

Protein Sequence

10 MAALKLLSSG 20 LRLGASARSS 30 RGALHKGCVC 40 YFSVSTRHHT 50 KFYTDPVEAV 60 KDIPNGATLL 70 VGGFGLCGIP 80 ENLIGALLKT 90 GVKDLTAVSN 100 NAGVDNFGLG 110 LLLRSKQIKR 120 MISSYVGENA 130 EFERQFLSGE 140 LEVELTPQGT 150 LAERIRAGGA 160 GVPAFYTSTG 170 YGTLVQEGGS 180 PIKYNKDGSV 190 AIASKPREVR 200 EFNGQHFILE 210 EAITGDFALV 220 KAWKADRAGN 230 VIFRKSARNF 240 NLPMCKAAGT 250 TVVEVEEIVD 260 IGSFAPEDIH 270 IPKIYVHRLI 280 KGEKYEKRIE 290 RLSLRKEGDG 300 KGKSGKPGGD 310 VRERIIKRAA 320 LEFEDGMYAN 330 LGIGIPLLAS 340 NFISPNMTVH 350 LQSENGVLGL 360 GPYPLKDEAD 370 ADLINAGKET 380 VTVLPGASFF 390 SSDESFAMIR 400 GGHVNLTMLG 410 AMQVSKYGDL 420 ANWMIPGKMV 430 KGMGGAMDLV 440 SSSKTKVVVT 450 MEHSAKGNAH 460 KIMEKCTLPL 470 TGKQCVNRII 480 TEKGVFDVDK 490 KNGLTLIELW 500 EGLTVDDIKK 510 STGCDFAVSP 520 NLMPMQQIST

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity
Biological Process GO:0060612 adipose tissue development
Biological Process GO:0007507 heart development
Biological Process GO:0046952 ketone body catabolic process
Biological Process GO:1902224 ketone body metabolic process
Biological Process GO:0042182 ketone catabolic process
Biological Process GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0014823 response to activity
Biological Process GO:0045471 response to ethanol
Biological Process GO:0009725 response to hormone
Biological Process GO:0007584 response to nutrient
Biological Process GO:0042594 response to starvation
Biological Process GO:0009410 response to xenobiotic stimulus

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.