Search Results

Overview

Uniprot ID	Q9D0S9
Protein Name	Adenosine 5'-monophosphoramidase HINT2
Gene Name	Hint2
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
128	IAQAQGLKDGYRLVV

Function

Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (By similarity). May be involved in steroid biosynthesis (By similarity). May play a role in apoptosis (By similarity)

Protein Sequence

10 MAAAVLLAVG 20 LRAARRTLAA 30 AGARGAQVRG 40 NAGVSDGSEV 50 AKAQKAAPGG 60 ASPTIFSRIL 70 DRSLPADILY 80 EDQQCLVFRD 90 VAPQAPVHFL 100 VIPRKPIPRI 110 SQAEEDDQQL 120 LGHLLLVAKK 130 IAQAQGLKDG 140 YRLVVNDGKM 150 GAQSVYHLHI 160 HVLGGRQLQW PPG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0043530	adenosine 5'-monophosphoramidase activity
Molecular Function	GO:0016787	hydrolase activity
Molecular Function	GO:0000166	nucleotide binding
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0016042	lipid catabolic process
Biological Process	GO:2000757	negative regulation of peptidyl-lysine acetylation
Biological Process	GO:0006694	steroid biosynthetic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.