Search Results
Overview
| Uniprot ID | Q9D1E6 |
|---|---|
| Protein Name | Tubulin-folding cofactor B |
| Gene Name | Tbcb |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 129 | RSFMKRSKLGPYNEE |
Function
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (By similarity). Involved in regulation of tubulin heterodimer dissociation (PubMed:17184771). May function as a negative regulator of axonal growth (PubMed:17217416)
Protein Sequence
10
MEVTGISAPT
20
VMVFISSSLN
30
SFRSEKRYSR
40
SLTIAEFKCK
50
LELVVGSPAS
60
CMELELYGAD
70
DKFYSKLDQE
80
DALLGSYPVD
90
DGCRIHVIDH
100
SGVRLGEYED
110
VSKVEKYEIS
120
PEAYERRQNT
130
VRSFMKRSKL
140
GPYNEELRAQ
150
QEAEAAQRLS
160
EEKAQASAIS
170
VGSRCEVRAP
180
DHSLRRGTVM
190
YVGLTDFKPG
200
YWVGVRYDEP
210
LGKNDGSVNG
220
KRYFECQAKY
230
GAFVKPSAVT
240
VGDFPEEDYG
LDEM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0035371 | microtubule plus-end |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0043014 | alpha-tubulin binding |
| Molecular Function | GO:0051010 | microtubule plus-end binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0031122 | cytoplasmic microtubule organization |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0007023 | post-chaperonin tubulin folding pathway |
| Biological Process | GO:0007021 | tubulin complex assembly |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.