Search Results

Overview

Uniprot IDQ9D2G2
Protein NameDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Gene NameDlst
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
155 GAAPAKAKPAETPAP
204 SKPVSAIKPTAAPPL
218 LAEAGAAKGLRSEHR
354 TINELGEKARKNELA

Function

Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity)

Protein Sequence

10 MLSRSRCVSR 20 AFSRSLSAFQ 30 KGNCPLGRRS 40 LPGVSLCRGP 50 GYPDNRKMVI 60 NSGSVFRVRF 70 FQTTAVCKND 80 VITVQTPAFA 90 ESVTEGDVRW 100 EKAVGDAVAE 110 DEVVCEIETD 120 KTSVQVPSPA 130 NGIIEALLVP 140 DGGKVEGGTP 150 LFTLRKTGAA 160 PAKAKPAETP 170 APAHKAEPAA 180 PAAPPPPAAP 190 VLTQMPPVPS 200 PSQPPSSKPV 210 SAIKPTAAPP 220 LAEAGAAKGL 230 RSEHREKMNR 240 MRQRIAQRLK 250 EAQNTCAMLT 260 TFNEVDMSNI 270 QEMRARHKDA 280 FLKKHNLKLG 290 FMSAFVKASA 300 FALQEQPVVN 310 AVIDDATKEV 320 VYRDYIDISV 330 AVATPRGLVV 340 PVIRNVETMN 350 YADIERTINE 360 LGEKARKNEL 370 AIEDMDGGTF 380 TISNGGVFGS 390 LFGTPIINPP 400 QSAILGMHAI 410 FDRPVAVGGK 420 VEVRPMMYVA 430 LTYDHRLIDG 440 REAVTFLRKI 450 KAAVEDPRVL LLDL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0160167 oxoadipate dehydrogenase complex
Cellular Component GO:0045252 oxoglutarate dehydrogenase complex
Cellular Component GO:0042383 sarcolemma
Molecular Function GO:0016746 acyltransferase activity
Molecular Function GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity
Molecular Function GO:0031072 heat shock protein binding
Molecular Function GO:0051087 protein-folding chaperone binding
Biological Process GO:0120551 2-oxoglutarate decarboxylation to succinyl-CoA
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0033512 L-lysine catabolic process to acetyl-CoA via L-saccharopine
Biological Process GO:0006104 succinyl-CoA metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.