Search Results
Overview
| Uniprot ID | Q9D3D9 |
|---|---|
| Protein Name | ATP synthase F(1) complex subunit delta, mitochondrial |
| Gene Name | Atp5f1d |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 136 | AARANLEKAQSELSG |
Function
Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0005740 | mitochondrial envelope |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045259 | proton-transporting ATP synthase complex |
| Cellular Component | GO:0120212 | sperm head-tail coupling apparatus |
| Cellular Component | GO:0097228 | sperm principal piece |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0015078 | proton transmembrane transporter activity |
| Molecular Function | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0033615 | mitochondrial proton-transporting ATP synthase complex assembly |
| Biological Process | GO:0015986 | proton motive force-driven ATP synthesis |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
| Biological Process | GO:1902600 | proton transmembrane transport |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.