Search Results

Overview

Uniprot ID	Q9D6J6
Protein Name	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Gene Name	Ndufv2
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
158	LQRKLGIKVGETTPD
211	IDELKAGKVPKPGPR

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains one iron-sulfur cluster

Protein Sequence

10 MFSLALRARA 20 TGLAAQWGRH 30 ARNLHKTAVH 40 NGAGGALFVH 50 RDTPENNPDT 60 PFDFTPENYK 70 RIEAIVKNYP 80 EGHQAAAVLP 90 VLDLAQRQNG 100 WLPISAMNKV 110 AEVLQVPPMR 120 VYEVATFYTM 130 YNRKPVGKYH 140 IQVCTTTPCM 150 LRDSDSILET 160 LQRKLGIKVG 170 ETTPDKLFTL 180 IEVECLGACV 190 NAPMVQINDN 200 YYEDLTPKDI 210 EEIIDELKAG 220 KVPKPGPRSG 230 RFCCEPAGGL 240 TSLTEPPKGP GFGVQAGL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0043209	myelin sheath
Cellular Component	GO:0045271	respiratory chain complex I
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0008137	NADH dehydrogenase (ubiquinone) activity
Molecular Function	GO:0016491	oxidoreductase activity
Biological Process	GO:0009060	aerobic respiration
Biological Process	GO:0048738	cardiac muscle tissue development
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0042776	proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.