Search Results

Overview

Uniprot IDQ9D6R2
Protein NameIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Gene NameIdh3a
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
100 MGLKGPLKTPIAAGH
116 SMNLLLRKTFDLYAN
214 SDGLFLQKCREVAEN
223 REVAENCKDIKFNEM
336 AACFATIKDGKSLTK
343 KDGKSLTKDLGGNAK
350 KDLGGNAKCSDFTEE
58 MKIFDAAKAPIQWEE

Function

Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers

Protein Sequence

10 MAGSAWVSKV 20 SRLLGAFHNT 30 KQVTRGFAGG 40 VQTVTLIPGD 50 GIGPEISASV 60 MKIFDAAKAP 70 IQWEERNVTA 80 IQGPGGKWMI 90 PPEAKESMDK 100 NKMGLKGPLK 110 TPIAAGHPSM 120 NLLLRKTFDL 130 YANVRPCVSI 140 EGYKTPYTDV 150 NIVTIRENTE 160 GEYSGIEHVI 170 VDGVVQSIKL 180 ITEEASKRIA 190 EFAFEYARNN 200 HRSNVTAVHK 210 ANIMRMSDGL 220 FLQKCREVAE 230 NCKDIKFNEM 240 YLDTVCLNMV 250 QDPSQFDVLV 260 MPNLYGDILS 270 DLCAGLIGGL 280 GVTPSGNIGA 290 NGVAIFESVH 300 GTAPDIAGKD 310 MANPTALLLS 320 AVMMLRHMGL 330 FDHAAKIEAA 340 CFATIKDGKS 350 LTKDLGGNAK 360 CSDFTEEICR RVKDLD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045242 isocitrate dehydrogenase complex (NAD+)
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Molecular Function GO:0004449 isocitrate dehydrogenase (NAD+) activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0051287 NAD binding
Biological Process GO:0006102 isocitrate metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.