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Overview

Uniprot ID	Q9D6U8
Protein Name	Protein FAM162A
Gene Name	Fam162a
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
63	RHGVPLHKPTDFEKK
70	KPTDFEKKILLWSGR

Function

Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (PubMed:17316997)

Protein Sequence

10 MWSLGGLRLA 20 AGHCLRLYER 30 NASSSLRFTR 40 NTDLKRINGF 50 CTKPQESPKT 60 PTQSYRHGVP 70 LHKPTDFEKK 80 ILLWSGRFKK 90 EEEIPETISF 100 EMLDAAKNKL 110 RVKVSYLMIA 120 LTVAGCIYMV 130 IEGKKAAKRH 140 ESLTSLNLER 150 KARLREEAAM KAKTD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031966	mitochondrial membrane
Cellular Component	GO:0005739	mitochondrion
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0051402	neuron apoptotic process
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.