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Overview

Uniprot IDQ9D7B6
Protein NameIsobutyryl-CoA dehydrogenase, mitochondrial
Gene NameAcad8
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
229 TPGLSFGKKEKKVGW
78 FPVDVMRKAAQLGFG

Function

Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway. To a lesser extent, also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA

Protein Sequence

10 MAMLRSGYRR 20 FGCLRAALKS 30 LAQTHHRSIT 40 FCIDPSLGLN 50 EEQKGFQKVA 60 FDFAAREMAP 70 NMAEWDQKEL 80 FPVDVMRKAA 90 QLGFGGVYVR 100 TDVGGSGLSR 110 LDTSVIFEAL 120 ATGCTSTTAY 130 ISIHNMCAWM 140 IDSFGNEEQR 150 HKFCPPLCTM 160 EKFASYCLTE 170 PGSGSDAASL 180 LTSAKQQGDH 190 YILNGSKAFI 200 SGGGESDIYV 210 VMCRTGGSGA 220 KGISCIVVEK 230 GTPGLSFGKK 240 EKKVGWNSQP 250 TRAVIFEDCA 260 VPVANRIGTE 270 GQGFLIAMKG 280 LNGGRINVAS 290 CSLGAAHASV 300 ILTQEHLKVR 310 KQFGAPLARS 320 QYLQFQLADM 330 ATKLVASRLM 340 IRTAAVALQE 350 EREDAVALCS 360 MAKLFATEEC 370 FAICNQALQM 380 HGGYGYLKDY 390 AVQQYMRDSR 400 VHQILEGSNE 410 VMRMLISRNL LQD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0003853 short-chain 2-methyl fatty acyl-CoA dehydrogenase activity
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0006574 L-valine catabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.