Search Results

Overview

Uniprot IDQ9D819
Protein NameInorganic pyrophosphatase
Gene NamePpa1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
57 VPRWSNAKMEIATKD

Function

Catalyzes the hydrolysis of inorganic diphosphate into two phosphate molecules (PubMed:24271717). Has MAP kinase serine/threonine phosphatase activity toward c-Jun N-terminal kinase (JNK) and, in neuronal cells, is involved in the negative regulation of neurite growth via JNK dephosphorylation (PubMed:23626709)

Protein Sequence

10 MSGFSSEERA 20 APFTLEYRVF 30 LKNEKGQYIS 40 PFHDVPIYAD 50 KDVFHMVVEV 60 PRWSNAKMEI 70 ATKDPLNPIK 80 QDVKKGKLRY 90 VANLFPYKGY 100 IWNYGAIPQT 110 WEDPGHSDKH 120 TGCCGDNDPI 130 DVCEIGSKVC 140 ARGEIIRVKV 150 LGILAMIDEG 160 ETDWKVIAIN 170 VDDPDAANYK 180 DISDVERLKP 190 GYLEATVDWF 200 RRYKVPDGKP 210 ENEFAFNAEF 220 KNKDFAVDII 230 KSTHDYWKAL 240 VTKKTDGKGI 250 SCMNTTVSES 260 PFKCDPDAAK 270 AIVDALPPPC 280 ESACSLPTDV DKWFHQQKN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0004427 inorganic diphosphate phosphatase activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0016462 pyrophosphatase activity
Biological Process GO:0006796 phosphate-containing compound metabolic process

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.