Search Results
Overview
| Uniprot ID | Q9D8T7 |
|---|---|
| Protein Name | SRA stem-loop-interacting RNA-binding protein, mitochondrial |
| Gene Name | Slirp |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 25 | RPIAFVRKIPWTAAA |
Function
RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity)
Protein Sequence
10
MAASAIKGLS
20
ALRSSTGRPI
30
AFVRKIPWTA
40
AASELREHFA
50
QFGHVRRCTV
60
PFDKETGFHR
70
GMGWVQFSSQ
80
EELQNALQQE
90
HHIIDGVKIH
100
VQAQRAKALH
110
GAQTSDEERF
LR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0036126 | sperm flagellum |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0034046 | poly(G) binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0097222 | mitochondrial mRNA polyadenylation |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:1905638 | negative regulation of mitochondrial mRNA catabolic process |
| Biological Process | GO:0000961 | negative regulation of mitochondrial RNA catabolic process |
| Biological Process | GO:0048026 | positive regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0007338 | single fertilization |
| Biological Process | GO:0007286 | spermatid development |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.