Search Results
Overview
| Uniprot ID | Q9DAW9 |
|---|---|
| Protein Name | Calponin-3 |
| Gene Name | Cnn3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 6 | **MTHFNKGPSYGLS |
Function
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)
Protein Sequence
10
MTHFNKGPSY
20
GLSAEVKNKI
30
ASKYDQQAEE
40
DLRNWIEEVT
50
GLGIGTNFQL
60
GLKDGIILCE
70
LINKLQPGSV
80
KKVNESSLNW
90
PQLENIGNFI
100
KAIQAYGMKP
110
HDIFEANDLF
120
ENGNMTQVQT
130
TLVALAGLAK
140
TKGFHTTIDI
150
GVKYAEKQTR
160
RFDEGKLKAG
170
QSVIGLQMGT
180
NKCASQAGMT
190
AYGTRRHLYD
200
PKMQTDKPFD
210
QTTISLQMGT
220
NKGASQAGML
230
APGTRRDIYD
240
QKLTLQPVDN
250
STISLQMGTN
260
KVASQKGMSV
270
YGLGRQVYDP
280
KYCAAPTEPV
290
IHNGSQGTGT
300
NGSEISDSDY
310
QAEYPDEYHG
320
EYPDDYPREY
330
QYGDDQGIDY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0098794 | postsynapse |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0031032 | actomyosin structure organization |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0032780 | negative regulation of ATP-dependent activity |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.