Search Results
Overview
| Uniprot ID | Q9DB15 |
|---|---|
| Protein Name | Large ribosomal subunit protein bL12m |
| Gene Name | Mrpl12 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | TVRLTEAKPVDKVKL |
| 145 | TEAKPVDKVKLIKEI |
| 153 | VKLIKEIKNYVQGIN |
| 165 | GINLVQAKKLVESLP |
| 166 | INLVQAKKLVESLPQ |
| 176 | ESLPQEIKANVAKAE |
| 181 | EIKANVAKAEAEKIK |
Function
As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation. When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription. Required for POLRMT stability
Protein Sequence
10
MLPVAASRCL
20
WGPRLGLRGA
30
ALRLARQQMP
40
SVCAARQLRS
50
SSHRRSEALA
60
GAPLDNAPKE
70
YPPKIQQLVQ
80
DIASLTLLEI
90
SDLNELLKKT
100
LKIQDVGLMP
110
MGGMVPGPVS
120
AAAPASEAAE
130
EEDVPKQKER
140
THFTVRLTEA
150
KPVDKVKLIK
160
EIKNYVQGIN
170
LVQAKKLVES
180
LPQEIKANVA
190
KAEAEKIKAA
200
LEAVGGTVVL
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005761 | mitochondrial ribosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003735 | structural constituent of ribosome |
| Biological Process | GO:0006390 | mitochondrial transcription |
| Biological Process | GO:0032543 | mitochondrial translation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0006412 | translation |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.