Search Results

Overview

Uniprot IDQ9DB20
Protein NameATP synthase peripheral stalk subunit OSCP, mitochondrial
Gene NameAtp5po
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
162 SELKTVLKSFLSPNQ
192 MIVRIGEKYVDMSAK
199 KYVDMSAKSKIQKLS
51 ALYSAASKEKKLDQV
54 SAASKEKKLDQVEKE
60 KKLDQVEKELLRVGQ
70 LRVGQLLKDPKVSLA
90 IKRTVKVKSLNDITK
97 KSLNDITKREKFSPL

Function

Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)

Protein Sequence

10 MAAPAASGLS 20 RQVRSFSTSV 30 VRPFAKLVRP 40 PVQVYGIEGR 50 YATALYSAAS 60 KEKKLDQVEK 70 ELLRVGQLLK 80 DPKVSLAVLN 90 PYIKRTVKVK 100 SLNDITKREK 110 FSPLTANLMN 120 LLAENGRLGN 130 TQGIISAFST 140 IMSVHRGEVP 150 CTVTTASPLD 160 DAVLSELKTV 170 LKSFLSPNQI 180 LKLEIKTDPS 190 IMGGMIVRIG 200 EKYVDMSAKS 210 KIQKLSKAMR EML

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045259 proton-transporting ATP synthase complex
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:1903924 estradiol binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0071345 cellular response to cytokine stimulus
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.