Search Results
Overview
| Uniprot ID | Q9DBF1 |
|---|---|
| Protein Name | Alpha-aminoadipic semialdehyde dehydrogenase |
| Gene Name | Aldh7a1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 390 | RAVEEAKKQGGTVVY |
Function
Aldehyde dehydrogenase enzyme that mediates important protective effects. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in cellular defense against hyperosmotic stress by metabolizing betaine aldehyde to betaine, an important cellular osmolyte and methyl donor
Protein Sequence
10
MWRVPRRLCV
20
QSVKTSKLSG
30
PWSRPAAHMS
40
TLLIHHPQYA
50
WLQDLGLRED
60
NEGVYNGSWG
70
GRGEVITTYC
80
PANNEPIARV
90
RQASLKDYEE
100
TIGKAKKAWN
110
IWADIPAPKR
120
GEIVRKIGDA
130
FREKIQLLGR
140
LVSLEMGKIL
150
VEGIGEVQEY
160
VDVCDYAAGL
170
SRMIGGPTLP
180
SERPGHALIE
190
MWNPLGLVGI
200
ITAFNFPVAV
210
FGWNNAIALI
220
TGNVCLWKGA
230
PTTSLVSVAV
240
TKIIAQVLED
250
NLLPGAICSL
260
VCGGADIGTT
270
MARDERVNLL
280
SFTGSTQVGK
290
EVALMVQERF
300
GKSLLELGGN
310
NAIIAFEDAD
320
LSLVVPSVLF
330
AAVGTAGQRC
340
TTVRRLFLHE
350
SIHNEVVDRL
360
RSAYSQIRVG
370
NPWDPNILYG
380
PLHTKQAVSM
390
FVRAVEEAKK
400
QGGTVVYGGK
410
VMDHPGNYVE
420
PTIVTGLAHD
430
APIVHQETFA
440
PILYVFKFQD
450
EEEVFEWNNE
460
VKQGLSSSIF
470
TKDLGRIFRW
480
LGPKGSDCGI
490
VNVNIPTSGA
500
EIGGAFGGEK
510
HTGGGRESGS
520
DAWKQYMRRS
530
TCTINYSTSL
PLAQGIKFQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:1905750 | negative regulation of endosome to plasma membrane protein transport |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004029 | aldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0008802 | betaine-aldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004043 | L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity |
| Molecular Function | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| Biological Process | GO:0008333 | endosome to lysosome transport |
| Biological Process | GO:0097009 | energy homeostasis |
| Biological Process | GO:0019285 | glycine betaine biosynthetic process from choline |
| Biological Process | GO:0006895 | Golgi to endosome transport |
| Biological Process | GO:0019477 | L-lysine catabolic process |
| Biological Process | GO:0006554 | lysine catabolic process |
| Biological Process | GO:0110076 | negative regulation of ferroptosis |
| Biological Process | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport |
| Biological Process | GO:0048227 | plasma membrane to endosome transport |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.