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Overview

Uniprot IDQ9DBJ1
Protein NamePhosphoglycerate mutase 1
Gene NamePgam1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
251 EAVAAQGKVKK****

Function

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate, a crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate

Protein Sequence

10 MAAYKLVLIR 20 HGESAWNLEN 30 RFSGWYDADL 40 SPAGHEEAKR 50 GGQALRDAGY 60 EFDICFTSVQ 70 KRAIRTLWTV 80 LDAIDQMWLP 90 VVRTWRLNER 100 HYGGLTGLNK 110 AETAAKHGEA 120 QVKIWRRSYD 130 VPPPPMEPDH 140 PFYSNISKDR 150 RYADLTEDQL 160 PSCESLKDTI 170 ARALPFWNEE 180 IVPQIKEGKR 190 VLIAAHGNSL 200 RGIVKHLEGL 210 SEEAIMELNL 220 PTGIPIVYEL 230 DKNLKPIKPM 240 QFLGDEETVR 250 KAMEAVAAQG KVKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990917 ooplasm
Cellular Component GO:0120083 rough endoplasmic reticulum cisterna
Cellular Component GO:0097228 sperm principal piece
Molecular Function GO:0004082 bisphosphoglycerate mutase activity
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0004619 phosphoglycerate mutase activity
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0046166 glyceraldehyde-3-phosphate biosynthetic process

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.