Search Results

Overview

Uniprot ID	Q9DBL1
Protein Name	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Gene Name	Acadsb
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
284	GKIGHGYKYAIGSLN
70	MMKQTVKKFAQEHVA
88	SSMDENSKMEKSVIQ

Function

Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug

Protein Sequence

10 MAVSALQLWR 20 MGGLLRRRFP 30 TCLSPWKIPP 40 RVLKSSQPEA 50 LVSLTNNAVA 60 FAPLQTLTDE 70 EIMMKQTVKK 80 FAQEHVAPLV 90 SSMDENSKME 100 KSVIQGLFQQ 110 GLMGIEVEAQ 120 YGGTEASFFC 130 SVLVIEELAK 140 VDASVALLCD 150 IQNTIINNLF 160 RKHASEEQKA 170 TYLPKLVTEK 180 LGSFCLSEAG 190 AGSDSFAMKT 200 RADKSGNYYV 210 LNGSKMWISH 220 AEHAELFLVF 230 ANVDPSSGYR 240 GITCFLVDRD 250 TEGFQIGKRE 260 NKMGIRASST 270 CQLTFENVKV 280 PETNILGKIG 290 HGYKYAIGSL 300 NEGRIGIAAQ 310 MLGLAQGCFD 320 YTIPYIKERM 330 QFGKRIFDFQ 340 GLQHQVAQVA 350 TQLEATRLLT 360 YNAARLVEAG 370 RPFIKEASMA 380 KYYASEVAGL 390 TTSKCIEWMG 400 GVGYTKDYPV 410 EKFFRDAKIG 420 TIYEGASNIQ 430 LNTIAKHIDA EY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0003995	acyl-CoA dehydrogenase activity
Molecular Function	GO:0009055	electron transfer activity
Molecular Function	GO:0050660	flavin adenine dinucleotide binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0003853	short-chain 2-methyl fatty acyl-CoA dehydrogenase activity
Molecular Function	GO:0016937	short-chain fatty acyl-CoA dehydrogenase activity
Biological Process	GO:0006637	acyl-CoA metabolic process
Biological Process	GO:0006635	fatty acid beta-oxidation
Biological Process	GO:0006631	fatty acid metabolic process
Biological Process	GO:0006550	L-isoleucine catabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.