Search Results
Overview
| Uniprot ID | Q9DC70 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial |
| Gene Name | Ndufs7 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | KMAPALRKVYDQMPE |
| 62 | GAGAVVPKLSHLPRS |
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I
Protein Sequence
10
MAALAAPGLL
20
SVRILGLRTA
30
QVQLRRVHQS
40
VATEGPSPSP
50
SPSLSSTQSA
60
VSKAGAGAVV
70
PKLSHLPRSR
80
AEYVVTKLDD
90
LINWARRSSL
100
WPMTFGLACC
110
AVEMMHMAAP
120
RYDMDRFGVV
130
FRASPRQADV
140
MIVAGTLTNK
150
MAPALRKVYD
160
QMPEPRYVVS
170
MGSCANGGGY
180
YHYSYSVVRG
190
CDRIVPVDIY
200
VPGCPPTAEA
210
LLYGILQLQR
220
KIKREQKLKI
WYRR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Cellular Component | GO:0097060 | synaptic membrane |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004497 | monooxygenase activity |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Molecular Function | GO:0003954 | NADH dehydrogenase activity |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0048038 | quinone binding |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0015990 | electron transport coupled proton transport |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0032981 | mitochondrial respiratory chain complex I assembly |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.