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Overview

Uniprot IDQ9DCS3
Protein NameEnoyl-[acyl-carrier-protein] reductase, mitochondrial
Gene NameMecr
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
222 VRDRPDIKKLTDRLK
248 ELRMPETKTIFKDLP
252 PETKTIFKDLPLPRL
267 ALNCVGGKSSTELLR
56 GNHGDPAKVVQLKNL

Function

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (By similarity). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (PubMed:30266742). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism (By similarity). Required for proper morphology and bioenergetic functions of mitochondria (By similarity). Required for maintenance of neurons (By similarity)

Protein Sequence

10 MLVSQRVTGA 20 RARAPQLAGL 30 LEAWYRHGRT 40 TSSYSALSEP 50 SRVRALVYGN 60 HGDPAKVVQL 70 KNLELTAVEG 80 SDVHVRMLAA 90 PINPSDINMI 100 QGNYGLLPKL 110 PAVGGNEGVG 120 QVIAVGSSVS 130 ALKPGDWVIP 140 ANAGLGTWRT 150 EAVFSEEALI 160 GIPKDIPLQS 170 AATLGVNPCT 180 AYRMLVDFEQ 190 LQPGDSVIQN 200 ASNSGVGQAV 210 IQIASALRLK 220 TINVVRDRPD 230 IKKLTDRLKD 240 LGADYVLTEE 250 ELRMPETKTI 260 FKDLPLPRLA 270 LNCVGGKSST 280 ELLRHLAPGG 290 TMVTYGGMAK 300 QPVTASVSLL 310 IFKDLKLRGF 320 WLSQWKKNHS 330 PDEFKELILT 340 LCNLIRQGRL 350 TAPSCSEVPL 360 QGYQQALEAS 370 MKPFVSSKQI LTM

Gene Ontology

Classification GO ID Description
Biological Process GO:0006879 intracellular iron ion homeostasis
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Molecular Function GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0046513 ceramide biosynthetic process
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0006631 fatty acid metabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.