Search Results
Overview
| Uniprot ID | Q9DCT2 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial |
| Gene Name | Ndufs3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 252 | RQPPESLKLEAGDKK |
| 258 | LKLEAGDKKPETK** |
| 259 | KLEAGDKKPETK*** |
| 42 | RESAAADKRPTVRPR |
| 55 | PRSDVTHKQLSAFGE |
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:31916679, PubMed:33148885, PubMed:38575788). Essential for the catalytic activity and assembly of complex I (PubMed:31916679, PubMed:33148885)
Protein Sequence
10
MAAAAARVWC
20
RGLLGAASVG
30
RGAGRPSVLW
40
QHVRRESAAA
50
DKRPTVRPRS
60
DVTHKQLSAF
70
GEYVAEILPK
80
YVQQVQVSCL
90
DELEICIHPD
100
GVIPTLTFLR
110
DHTNAQFKSL
120
ADLTAVDVPT
130
RQNRFEIVYN
140
LLSLRFNSRI
150
RVKTYADELT
160
PIDSIVSVHI
170
AANWYEREVW
180
DMFGVFFFNH
190
PDLRRILTDY
200
GFEGHPFRKD
210
FPLTGYVELR
220
YDDEVKRVVA
230
EPVELAQEFR
240
KFDLNSPWEA
250
FPAYRQPPES
260
LKLEAGDKKP
ETK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0009060 | aerobic respiration |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Cellular Component | GO:0097228 | sperm principal piece |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Molecular Function | GO:0003954 | NADH dehydrogenase activity |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0032981 | mitochondrial respiratory chain complex I assembly |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
| Biological Process | GO:0072593 | reactive oxygen species metabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.