Search Results

Overview

Uniprot IDQ9DCW4
Protein NameElectron transfer flavoprotein subunit beta
Gene NameEtfb
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
110 QVARVLAKLAEKEKV
116 AKLAEKEKVDLLFLG
176 GLETLRLKLPAVVTA
210 KKKIEVVKAGDLGVD
238 PQRSAGVKVETTEDL
248 TTEDLVAKLKEVGRI
26 KIRVKPDKSGVVTDG
59 LKEKKLVKEIIAVSC

Function

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (By similarity). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:25023281). ETFB binds an AMP molecule that probably has a purely structural role (By similarity)

Protein Sequence

10 MAELRALVAV 20 KRVIDFAVKI 30 RVKPDKSGVV 40 TDGVKHSMNP 50 FCEIAVEEAV 60 RLKEKKLVKE 70 IIAVSCGPSQ 80 CQETIRTALA 90 MGADRGIHVE 100 IPGAQAESLG 110 PLQVARVLAK 120 LAEKEKVDLL 130 FLGKQAIDDD 140 CNQTGQMTAG 150 LLDWPQGTFA 160 SQVTLEGDKV 170 KVEREIDGGL 180 ETLRLKLPAV 190 VTADLRLNEP 200 RYATLPNIMK 210 AKKKKIEVVK 220 AGDLGVDLTS 230 KVSVISVEEP 240 PQRSAGVKVE 250 TTEDLVAKLK EVGRI

Gene Ontology

Classification GO ID Description
Biological Process GO:0009063 amino acid catabolic process
Biological Process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
Biological Process GO:0022904 respiratory electron transport chain
Cellular Component GO:0045251 electron transfer flavoprotein complex
Cellular Component GO:0017133 mitochondrial electron transfer flavoprotein complex
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0000166 nucleotide binding

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.