Overview
| Uniprot ID | Q9DCZ4 |
|---|
| Protein Name | MICOS complex subunit Mic26 |
|---|
| Gene Name | Apoo |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 187 |
LWKQNFQKPGNVKNS |
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (By similarity). Can induce cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (By similarity)
Protein Sequence
10
MFKVIQRSVG
20
PASLSLLTFR
30
VYAAPKKDSP
40
HKSYMKIDEL
50
SLYSVPEGQS
60
KYVEEPRTQL
70
EENISQLRHH
80
CEPYTSFCQE
90
IYSHTKPKVD
100
HFVQWGVDNY
110
NYLQNAPPGF
120
FPRLGVIGFA
130
GFVGLLFARG
140
SKIKKLVYPP
150
FFMGLGASVY
160
YPQQAITIAQ
170
ITGEKLYDWG
180
LRGYIVIEDL
190
WKQNFQKPGN
VKNSPGNK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0061617 |
MICOS complex |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Biological Process |
GO:0042407 |
cristae formation |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.