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Overview

Uniprot ID	Q9EP89
Protein Name	Serine beta-lactamase-like protein LACTB, mitochondrial
Gene Name	Lactb
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
241	YKALKMVKGTPPPSD
270	KSDAPKAKVEQDSEA
288	SAKPGKKKNDFEQGE

Function

Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (By similarity). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (By similarity). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (By similarity). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758)

Protein Sequence

10 MYRLLSSVTA 20 RAAATAGPAW 30 DGGRRGAHRR 40 PGLPVLGLGW 50 AGGLGLGLGL 60 ALGAKLVVGL 70 RGAVPIQSPA 80 DPEASGTTEL 90 SHEQALSPGS 100 PHTPAPPAAR 110 GFSRAIESSR 120 DLLHRIKDEV 130 GAPGIVVGVS 140 VDGKEVWSEG 150 LGYADVENRV 160 PCKPETVMRI 170 ASISKSLTMV 180 ALAKLWEAGK 190 LDLDLPVQHY 200 VPEFPEKEYE 210 GEKVSVTTRL 220 LISHLSGIRH 230 YEKDIKKVKE 240 EKAYKALKMV 250 KGTPPPSDQE 260 KELKEKGGKN 270 NEKSDAPKAK 280 VEQDSEARCR 290 SAKPGKKKND 300 FEQGELYLKE 310 KFENSIESLR 320 LFKNDPLFFK 330 PGSQFLYSTF 340 GYTLLAAIVE 350 RASGYKYLDY 360 MQKIFHDLDM 370 LTTVQEENEP 380 VIYNRARFYV 390 YNKKKRLVNT 400 PYVDNSYKWA 410 GGGFLSTVGD 420 LLKFGNAMLY 430 GYQVGQFKNS 440 NENLLPGYLK 450 PETMVMMWTP 460 VPNTEMSWDK 470 EGKYAMAWGV 480 VEKKQTYGSC 490 RKQRHYASHT 500 GGAVGASSVL 510 LVLPEELDSE 520 AVNNKVPPRG 530 IIVSIICNMQ 540 SVGLNSTALK 550 IALEFDKDRA D

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0008233	peptidase activity
Biological Process	GO:0006629	lipid metabolic process
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0019216	regulation of lipid metabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.