Search Results
Overview
| Uniprot ID | Q9EQP2 |
|---|---|
| Protein Name | EH domain-containing protein 4 |
| Gene Name | Ehd4 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 302 | RKLNDLIKRARLAKV |
Function
ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:15930129). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (PubMed:33972531)
Protein Sequence
10
MFSWMGRQAG
20
GRERSGGMDA
30
VQTVTGGLRS
40
LYQRKVLPLE
50
EAYRFHEFHS
60
PALEDADFEN
70
KPMILLVGQY
80
STGKTTFIRY
90
LLEQDFPGMR
100
IGPEPTTDSF
110
IAVMYGETEG
120
STPGNALVVD
130
PKKPFRKLSR
140
FGNAFLNRFM
150
CSQLPNQVLK
160
SISIIDSPGI
170
LSGEKQRISR
180
GYDFCQVLQW
190
FAERVDRIIL
200
LFDAHKLDIS
210
DEFSEAIKAF
220
RGQDDKIRVV
230
LNKADQVDTQ
240
QLMRVYGALM
250
WSLGKVINTP
260
EVLRVYIGSF
270
WAQPLQNTDN
280
RRLFEAEAQD
290
LFRDIQSLPQ
300
KAAVRKLNDL
310
IKRARLAKVH
320
AYIISYLKKE
330
MPNMFGKENK
340
KRELIYRLPE
350
IYVQLQREYQ
360
ISAGDFPEVK
370
AMQEQLENYD
380
FTKFHSLKPK
390
LIEAVDNMLT
400
NKISSLMGLI
410
SQEEMNMPTQ
420
MVQGGAFDGT
430
TEGPFNQGYG
440
EGAKEGADEE
450
EWVVAKDKPV
460
YDELFYTLSP
470
INGKISGVNA
480
KKEMVTSKLP
490
NSVLGKIWKL
500
ADCDCDGMLD
510
EEEFALAKHL
520
IKIKLDGYEL
530
PNSLPPHLVP
540
PSHRKSLPKA
D
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0002042 | cell migration involved in sprouting angiogenesis |
| Biological Process | GO:0071363 | cellular response to growth factor stimulus |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0006907 | pinocytosis |
| Biological Process | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| Biological Process | GO:0051260 | protein homooligomerization |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0030100 | regulation of endocytosis |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.