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Overview

Uniprot IDQ9ERU9
Protein NameE3 SUMO-protein ligase RanBP2
Gene NameRanbp2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
2181 AKLYRYDKDVGQWKE

Function

E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Inhibits EIF4E-dependent mRNA export. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity

Protein Sequence

10 MRRSKADVER 20 YIASVQGSAP 30 SPREKSMKGF 40 YFAKLYYEAK 50 EYDLAKKYIS 60 TYINVQERDP 70 KAHRFLGLLY 80 EVEENIDKAV 90 ECYKRSVELN 100 PTQKDLVLKI 110 AELLCKNDVT 120 DGRAKYWVER 130 AAKLFPGSPA 140 IYKLKEQLLD 150 CKGEDGWNKL 160 FDLIQSELYA 170 RPDDIHVNIR 180 LVELYRSNKR 190 LKDAVAHCHE 200 ADRNTALRSS 210 LEWNLCVVQT 220 LKEYLESLQC 230 LDSDKSTWRA 240 TNKDLLLAYA 250 NLMLLTLSTR 260 DVQEGRELLE 270 SFDSALQSVK 280 SSVGGNDELS 290 ATFLETKGHF 300 YMHVGSLLLK 310 MGQQSDIQWR 320 ALSELAALCY 330 LVAFQVPRPK 340 VKLIKGEAGQ 350 NLLETMAHDR 360 LSQSGHMLLN 370 LSRGKQDFLK 380 EVVESFANKS 390 GQSALCDALF 400 SSQSSKERSF 410 LGNDDIGNLD 420 GQVPDPDDLA 430 RYDTGAVRAH 440 NGSLQHLTWL 450 GLQWNSLSTL 460 PAIRKWLKQL 470 FHHLPQETSR 480 LETNAPESIC 490 ILDLEVFLLG 500 VIYTSHLQLK 510 EKCNSHHTSY 520 QPLCLPLPVC 530 RQLCTERQKT 540 WWDAVCTLIH 550 RKALPGTSAK 560 LRLLVQREIN 570 SLRGQEKHGL 580 QPALLVHWAQ 590 SLQKTGSSLN 600 SFYDQREYIG 610 RSVHYWRKVL 620 PLLKMIRKKN 630 SIPEPIDPLF 640 KHFHSVDIQA 650 SEIGEYEEDA 660 HITFAILDAV 670 NGNIEDAMTA 680 FESIKNVVSY 690 WNLALIFHRK 700 AEDIENDALS 710 PEEQEECKNY 720 LRKTRDYLIR 730 ILDDSDSNTS 740 VVQKLPVPLE 750 SVKEMLNSVM 760 QELEDYSEGG 770 TLYKNGCWRS 780 ADSELKHSTP 790 SPTKYSLSPS 800 KSYKYSPKTP 810 PRWAEDQNSL 820 LKMICQQVEA 830 IKKEMQELKL 840 NSNNSASPHR 850 WPAEPYGQDP 860 APDGYQGSQT 870 FHGAPLTVAT 880 TGPSVYYSQS 890 PAYNSQYLLR 900 PAANVTPTKG 910 PVYGMNRLPP 920 QQHIYAYSQQ 930 MHTPPVQSSS 940 ACMFSQEMYG 950 PPLRFESPAT 960 GILSPRGDDY 970 FNYNVQQTST 980 NPPLPEPGYF 990 TKPPLVAHAS 1000 RSAESKVIEF 1010 GKSNFVQPMQ 1020 GEVIRPPLTT 1030 PAHTTQPTPF 1040 KFNSNFKSND 1050 GDFTFSSPQV 1060 VAQPPSTAYS 1070 NSESLLGLLT 1080 SDKPLQGDGY 1090 SGLKPISGQA 1100 SGSRNTFSFG 1110 SKNTLTENMG 1120 PNQQKNFGFH 1130 RSDDMFAFHG 1140 PGKSVFTTAA 1150 SELANKSHET 1160 DGGSAHGDEE 1170 DDGPHFEPVV 1180 PLPDKIEVKT 1190 GEEDEEEFFC 1200 NRAKLFRFDG 1210 ESKEWKERGI 1220 GNVKILRHKT 1230 SGKIRLLMRR 1240 EQVLKICANH 1250 YISPDMKLTP 1260 NAGSDRSFVW 1270 HALDYADELP 1280 KPEQLAIRFK 1290 TPEEAALFKC 1300 KFEEAQNILK 1310 ALGTNTSTAP 1320 NHTLRIVKES 1330 ATQDNKDICK 1340 ADGGNLNFEF 1350 QIVKKEGPYW 1360 NCNSCSFKNA 1370 ATAKKCVSCQ 1380 NTNPTSNKEL 1390 LGPPLVENGF 1400 APKTGLENAQ 1410 DRFATMTANK 1420 EGHWDCSVCL 1430 VRNEPTVSRC 1440 IACQNTKSAS 1450 SFVQTSFKFG 1460 QGDLPKSVDS 1470 DFRSVFSKKE 1480 GQWECSVCLV 1490 RNERSAKKCV 1500 ACENPGKQFK 1510 EWHCSLCSVK 1520 NEAHAIKCVA 1530 CNNPVTPSLS 1540 TAPPSFKFGT 1550 SEMSKPFRIG 1560 FEGMFAKKEG 1570 QWDCSLCFVR 1580 NEASATHCIA 1590 CQYPNKQNQP 1600 TSCVSAPASS 1610 ETSRSPKSGF 1620 EGLFPKKEGE 1630 WECAVCSVQN 1640 ESSSLKCVAC 1650 EASKPTHKPH 1660 EAPSAFTVGS 1670 KSQSNESAGS 1680 QVGTEFKSNF 1690 PEKNFKVGIS 1700 EQKFKFGHVD 1710 QEKTPSFAFQ 1720 GGSNTEFKSI 1730 KDGFSFCIPV 1740 SADGFKFGIQ 1750 EKGNQEKKSE 1760 KHLENDPSFQ 1770 AHDTSGQKNG 1780 SGVVFGQTSS 1790 TFTFADLAKS 1800 TSREGFQFGK 1810 KDPNFKGFSG 1820 AGEKLFSSQS 1830 GKVAEKANTS 1840 SDLEKDDDAY 1850 KTEDSDDIHF 1860 EPVVQMPEKV 1870 ELVTGEEDEK 1880 VLYSQRVKLF 1890 RFDAEISQWK 1900 ERGLGNLKIL 1910 KNEVNGKLRM 1920 LMRREQVLKV 1930 CANHWITTTM 1940 NLKPLSGSDR 1950 AWMWLASDFS 1960 DGDAKLEQLA 1970 AKFKTPELAE 1980 EFKQKFEECQ 1990 RLLLDIPLQT 2000 PHKLVDTGRA 2010 AKLIQRAEEM 2020 KSGLKDFKTF 2030 LTNDQVKVTD 2040 EENASSGADA 2050 PSASDTTAKQ 2060 NPDNTGPALE 2070 WDNYDLREDA 2080 LDDSVSSSSV 2090 HASPLASSPV 2100 RKNLFRFGES 2110 TTGFNFSFKS 2120 ALSPSKSPAK 2130 LNQSGASVGT 2140 DEESDVTQEE 2150 ERDGQYFEPV 2160 VPLPDLVEVS 2170 SGEENEQVVF 2180 SHRAKLYRYD 2190 KDVGQWKERG 2200 IGDIKILQNY 2210 DNKQVRIVMR 2220 RDQVLKLCAN 2230 HRITPDMTLQ 2240 TMKGTERVWV 2250 WTACDFADGE 2260 RKIEHLAVRF 2270 KLQDVADSFK 2280 KIFDEAKTAQ 2290 EKDSLITPHV 2300 SHLSTPRESP 2310 CGKIAIAVLE 2320 ETTRERTDLT 2330 QGDEVIDTTS 2340 EAGETSSTSE 2350 TTPKAVVSPP 2360 KFVFGSESVK 2370 SIFSSEKSKP 2380 FAFGNSSATG 2390 SLFGFSFNAP 2400 LKNSNSEMTS 2410 RVQSGSEGKV 2420 KPDKCELPQN 2430 SDIKQSSDGK 2440 VKNLSAFSKE 2450 NSSTSYTFKT 2460 PEKAQEKSKP 2470 EDLPSDNDIL 2480 IVYELTPTPE 2490 QKALAEKLLL 2500 PSTFFCYKNR 2510 PGYVSEEEED 2520 DEDYEMAVKK 2530 LNGKLYLDDS 2540 EKPLEENLAD 2550 NDKECVIVWE 2560 KKPTVEERAK 2570 ADTLKLPPTF 2580 FCGVCSDTDE 2590 DNGNGEDFQS 2600 ELRKVCEAQK 2610 SQNEKVTDRV 2620 GIEHIGETEV 2630 TNPVGCKSEE 2640 PDSDTKHSSS 2650 SPVSGTMDKP 2660 VDLSTRKETD 2670 MEFPSKGENK 2680 PVLFGFGSGT 2690 GLSFADLASS 2700 NSGDFAFGSK 2710 DKNFQWANTG 2720 AAVFGTQTTS 2730 KGGEDEDGSD 2740 EDVVHNEDIH 2750 FEPIVSLPEV 2760 EVKSGEEDEE 2770 VLFKERAKLY 2780 RWDRDVSQWK 2790 ERGIGDIKIL 2800 WHTMKKYYRI 2810 LMRRDQVFKV 2820 CANHVITKAM 2830 ELKPLNVSNN 2840 ALVWTASDYA 2850 DGEAKVEQLA 2860 VRFKTKEMTE 2870 SFKKKFEECQ 2880 QNIIKLQNGH 2890 TSLAAELSKD 2900 TNPVVFFDVC 2910 ADGEPLGRII 2920 MELFSNIVPQ 2930 TAENFRALCT 2940 GEKGFGFKNS 2950 IFHRVVPDFI 2960 CQGGDITKYN 2970 GTGGQSIYGD 2980 KFDDENFDLK 2990 HTGPGLLSMA 3000 NYGQNTNSSQ 3010 FFITLKKAEH 3020 LDFKHVVFGF 3030 VKDGMDTVRK 3040 IESFGSPKGS 3050 VSRRICITEC GQL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005642 annulate lamellae
Cellular Component GO:1990723 cytoplasmic periphery of the nuclear pore complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0042405 nuclear inclusion body
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0044614 nuclear pore cytoplasmic filaments
Cellular Component GO:0044615 nuclear pore nuclear basket
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0106068 SUMO ligase complex
Molecular Function GO:0019209 kinase activator activity
Molecular Function GO:0003755 peptidyl-prolyl cis-trans isomerase activity
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0061665 SUMO ligase activity
Molecular Function GO:0019789 SUMO transferase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051642 centrosome localization
Biological Process GO:0002753 cytoplasmic pattern recognition receptor signaling pathway
Biological Process GO:0051028 mRNA transport
Biological Process GO:0045824 negative regulation of innate immune response
Biological Process GO:0046832 negative regulation of RNA export from nucleus
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006607 NLS-bearing protein import into nucleus
Biological Process GO:0051168 nuclear export
Biological Process GO:0006913 nucleocytoplasmic transport
Biological Process GO:0006457 protein folding
Biological Process GO:0016925 protein sumoylation
Biological Process GO:0006111 regulation of gluconeogenesis
Biological Process GO:0001975 response to amphetamine
Biological Process GO:0002224 toll-like receptor signaling pathway

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.