Overview
| Uniprot ID | Q9GKE8 |
|---|
| Protein Name | Leukocyte surface antigen CD47 |
|---|
| Gene Name | CD47 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 63 |
VKWKFKGKDIFIFDG |
Function
Adhesive protein that mediates cell-to-cell interactions (PubMed:12153520). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:12153520). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (By similarity). Plays a role in modulating pulmonary endothelin EDN1 signaling (By similarity). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (By similarity). In response to THBS1, negatively modulates wound healing. Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (By similarity). May prevent premature elimination of red blood cells (By similarity)
Protein Sequence
10
MWPLVVVVLL
20
GSAYCGSAQL
30
IFNITKSVEF
40
TVCNTTVTIP
50
CFVNNMEAKN
60
ISELYVKWKF
70
KGKDIFIFDG
80
AQHISKPSEA
90
FPSSKISPSE
100
LLHGIASLKM
110
DKRDAVIGNY
120
TCEVTELSRE
130
GETIIELKRR
140
FVSWFSPNEN
150
ILIVIFPILA
160
ILLFWGQFGI
170
LTLKYKSSYT
180
KEKTIFLLVA
190
GLMLTIIVIV
200
GAILFIPGEY
210
STKNACGLGL
220
IVIPTAILIL
230
LQYCVFMMAL
240
GMSSFTIAIL
250
ILQVLGHVLS
260
VVGLSLCVSE
270
CTPVHGPLLI
280
SGLGIIALAE
290
LLGLVYMKCV
300
ASDHKTIQPP
RNN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0070053 |
thrombospondin receptor activity |
| Biological Process |
GO:0098609 |
cell-cell adhesion |
| Biological Process |
GO:0022409 |
positive regulation of cell-cell adhesion |
| Biological Process |
GO:0002684 |
positive regulation of immune system process |
| Biological Process |
GO:0050729 |
positive regulation of inflammatory response |
| Biological Process |
GO:0050766 |
positive regulation of phagocytosis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.