Overview
| Uniprot ID | Q9GKX6 |
|---|
| Protein Name | Galactose mutarotase |
|---|
| Gene Name | GALM |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 254 |
CLKRSKEKQFCARVH |
| 293 |
LDGTLKGKTGAVYPK |
Function
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose
Protein Sequence
10
MVSVTRSVFG
20
DLPSGAGTVE
30
KFQLQSDQLR
40
VDIISWGCTI
50
TALEVKDRQG
60
RASDVVLGFA
70
ELKEYLQKHP
80
YFGAVVGRVA
90
NRIAKGTFTL
100
DGKEYKLAIN
110
NGPNSLHGGV
120
RGFDKVLWTP
130
RVLSNGIEFS
140
RVSPDGEEGY
150
PGELKVWVTY
160
TLDGGELVVN
170
YRAQASQTTP
180
VNLTNHSYFN
190
LAGQGSPNIY
200
DHEVTIEADA
210
FLPVDETLIP
220
TGEIAPVQGT
230
AFDLRKPVEL
240
GKHLQEFHIN
250
GFDHNFCLKR
260
SKEKQFCARV
270
HHAGSGRVLE
280
VYTTQPGIQF
290
YTGNFLDGTL
300
KGKTGAVYPK
310
HSGFCLETQN
320
WPNAVNQPHF
330
PPVLLKPGEE
340
YNHTTWFVFS
VA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0004034 |
aldose 1-epimerase activity |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Biological Process |
GO:0033499 |
galactose catabolic process via UDP-galactose, Leloir pathway |
| Biological Process |
GO:0006006 |
glucose metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.