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Overview

Uniprot IDQ9GL01
Protein NameDolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Gene NameRPN2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
312 TVKLEHAKSVASRAT
402 TRVTYPAKAKGPFIA
443 FVRLHNQKTGQEVVF
70 AQVPDEKKACTFIKS

Function

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity

Protein Sequence

10 MAPPGSRTVL 20 LLALTIIART 30 QALKPTHYLT 40 KHDVERLKAS 50 LDRPFTSLES 60 AFYSIVGLSS 70 LGAQVPDEKK 80 ACTFIKSNLD 90 PSNVDSLFYP 100 PQSSQALSGC 110 EISISNETKD 120 LLLAAVSEDS 130 SVTQIYHAVA 140 ALSGFGLPLA 150 SQEALGALTA 160 RLSKEETVLA 170 TVQALQTASY 180 LSQQADLRSI 190 VEEIEDLVAR 200 LDELGGVYLQ 210 FEEGLLETTA 220 LFVAATYKLM 230 DHEGTEPSIK 240 EDQVIQLMNT 250 IFSKKNFESL 260 PEAFSVASAA 270 AALSQNRYHV 280 PVVVVPEGSP 290 SDTQEQAFLR 300 LQVTNVLSQP 310 LTQATVKLEH 320 AKSVASRATV 330 LQKTSFTPVG 340 DVFELNFVNV 350 KFSSGYYDFS 360 VKVEGDNRYI 370 ANTVELRVKI 380 STEVGITNVD 390 LSTVDKDQSI 400 APKTTRVTYP 410 AKAKGPFIAD 420 SPQNFALFFQ 430 LVDVNTGAEL 440 TPHQTFVRLH 450 NQKTGQEVVF 460 VAEPDSKNVY 470 RFELDTSERK 480 IEFDSASGTY 490 TLYLIIGDAT 500 LKNPIHWNVA 510 DVVIRFPEED 520 APSTVLSKNL 530 FTAKQEIQHL 540 FRDPEKRPPT 550 VVSNTFTGLI 560 LSPLLLLFAL 570 WIRIGAKISN 580 FTFGLTIIFH 590 LGHAMLAMYV 600 YWTQLNMFQT 610 LKYLAILGSV 620 TFLAGNRMLA QQAIKRTAH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0008250 oligosaccharyltransferase complex
Biological Process GO:0006487 protein N-linked glycosylation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.