Overview
| Uniprot ID | Q9GL51 |
|---|
| Protein Name | Platelet-activating factor acetylhydrolase IB subunit alpha |
|---|
| Gene Name | PAFAH1B1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 147 |
GDFERTLKGHTDSVQ |
| 266 |
RVWVVATKECKAELR |
| 269 |
VVATKECKAELREHE |
| 360 |
ILSCADDKTLRVWDY |
| 368 |
TLRVWDYKNKRCMKT |
| 46 |
MNEELDKKYAGLLEK |
| 54 |
YAGLLEKKWTSVIRL |
Function
Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity)
Protein Sequence
10
MVLSQRQRDE
20
LNRAIADYLR
30
SNGYEEAYSV
40
FKKEAELDMN
50
EELDKKYAGL
60
LEKKWTSVIR
70
LQKKVMELES
80
KLNEAKEEFT
90
SGGPLGQKRD
100
PKEWIPRPPE
110
KYALSGHRSP
120
VTRVIFHPVF
130
SVMVSASEDA
140
TIKVWDYETG
150
DFERTLKGHT
160
DSVQDISFDH
170
SGKLLASCSA
180
DMTIKLWDFQ
190
GFECIRTMHG
200
HDHNVSSVAI
210
MPNGDHIVSA
220
ARDKTIKMWE
230
VQTGYCVKTF
240
TGHREWVRMV
250
RPNQDGTLIA
260
SCSNDQTVRV
270
WVVATKECKA
280
ELREHEHVVE
290
CISWAPESSY
300
SSISEATGSE
310
TKKSGKPGPF
320
LLSGSRDKTI
330
KMWDVSTGMC
340
LMTLVGHDNW
350
VRGVLFHSGG
360
KFILSCADDK
370
TLRVWDYKNK
380
RCMKTLNAHE
390
HFVTSLDFHK
400
TAPYVVTGSV
410
DQTVKVWECR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008247 |
1-alkyl-2-acetylglycerophosphocholine esterase complex |
| Cellular Component |
GO:1904115 |
axon cytoplasm |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005881 |
cytoplasmic microtubule |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0005875 |
microtubule associated complex |
| Cellular Component |
GO:0043005 |
neuron projection |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Cellular Component |
GO:0031965 |
nuclear membrane |
| Cellular Component |
GO:0005819 |
spindle |
| Molecular Function |
GO:0070840 |
dynein complex binding |
| Molecular Function |
GO:0051010 |
microtubule plus-end binding |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Biological Process |
GO:0048854 |
brain morphogenesis |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0000132 |
establishment of mitotic spindle orientation |
| Biological Process |
GO:0007281 |
germ cell development |
| Biological Process |
GO:0016042 |
lipid catabolic process |
| Biological Process |
GO:0031023 |
microtubule organizing center organization |
| Biological Process |
GO:0051012 |
microtubule sliding |
| Biological Process |
GO:0007097 |
nuclear migration |
| Biological Process |
GO:0038026 |
reelin-mediated signaling pathway |
| Biological Process |
GO:0008090 |
retrograde axonal transport |
| Biological Process |
GO:0047496 |
vesicle transport along microtubule |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.