Overview
| Uniprot ID | Q9GLP0 |
|---|
| Protein Name | Integrin beta-1 |
|---|
| Gene Name | ITGB1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 134 |
EPQTFTLKFKRAEDY |
| 238 |
VFNELVGKQRISGNL |
| 29 |
ADENRCLKANAKSCG |
| 438 |
TANKCPNKNSETIKI |
| 619 |
VCECGVCKCTDPKFQ |
| 654 |
VQCRAFNKGEKKDTC |
| 678 |
TKVENRDKLPQPGQV |
| 692 |
VDPLSHCKEKDVDDC |
| 73 |
DLEALRKKGCHPDDI |
| 765 |
HDRREFAKFEKEKMN |
| 794 |
VTTVVNPKYEGK*** |
| 93 |
SKNIKKNKNVTNRSK |
Function
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (By similarity)
Protein Sequence
10
MNLQLIFWIG
20
LISSVCYVFG
30
QADENRCLKA
40
NAKSCGECIQ
50
AGPNCGWCTN
60
STFLQEGMPT
70
SARCDDLEAL
80
RKKGCHPDDI
90
ENPRGSKNIK
100
KNKNVTNRSK
110
GTAEKLQPED
120
ITQIQPQQLV
130
LQLRSGEPQT
140
FTLKFKRAED
150
YPIDLYYLMD
160
LSYSMKDDLE
170
NVKSLGTDLM
180
NEMRRITSDF
190
RIGFGSFVEK
200
TVMPYISTTP
210
AKLRNPCTSE
220
QNCTSPFSYK
230
NVLSLTDKGE
240
VFNELVGKQR
250
ISGNLDSPEG
260
GFDAIMQVAV
270
CGSLIGWRNV
280
TRLLVFSTDA
290
GFHFAGDGKL
300
GGIVLPNDGH
310
CHLENDVYTM
320
SHYYDYPSIA
330
HLVQKLSENN
340
IQTIFAVTEE
350
FQPVYKELKN
360
LIPKSAVGTL
370
SANSSNVIQL
380
IIDAYNSLSS
390
EVILENSKLP
400
EGVTINYKSY
410
CKNGVNGTGE
420
NGRKCSNISI
430
GDEVQFEISI
440
TANKCPNKNS
450
ETIKIKPLGF
460
TEEVEIILQF
470
ICECECQSEG
480
IPSSPKCHDG
490
NGTFECGACR
500
CNEGRVGRHC
510
ECSTDEVNSE
520
DMDAYCRKEN
530
SSEICTNNGE
540
CVCGQCVCRK
550
RDNTNEIYSG
560
KFCECDNFNC
570
DRSNGLICGG
580
NGVCKCRVCE
590
CNPNYTGSAC
600
DCSLDTTSCM
610
AVNGQICNGR
620
GVCECGVCKC
630
TDPKFQGPTC
640
EMCQTCLGVC
650
AEHKECVQCR
660
AFNKGEKKDT
670
CAQECSHFNI
680
TKVENRDKLP
690
QPGQVDPLSH
700
CKEKDVDDCW
710
FYFTYSVNGN
720
NEATVHVVET
730
PECPTGPDII
740
PIVAGVVAGI
750
VLIGLALLLI
760
WKLLMIIHDR
770
REFAKFEKEK
780
MNAKWDTGEN
790
PIYKSAVTTV
VNPKYEGK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0034679 |
integrin alpha9-beta1 complex |
| Cellular Component |
GO:0008305 |
integrin complex |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0042470 |
melanosome |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0055037 |
recycling endosome |
| Cellular Component |
GO:0032587 |
ruffle membrane |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0098639 |
collagen binding involved in cell-matrix adhesion |
| Molecular Function |
GO:0001968 |
fibronectin binding |
| Molecular Function |
GO:0005178 |
integrin binding |
| Molecular Function |
GO:0098640 |
integrin binding involved in cell-matrix adhesion |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Biological Process |
GO:0033627 |
cell adhesion mediated by integrin |
| Biological Process |
GO:0016477 |
cell migration |
| Biological Process |
GO:0098609 |
cell-cell adhesion |
| Biological Process |
GO:0007160 |
cell-matrix adhesion |
| Biological Process |
GO:0071404 |
cellular response to low-density lipoprotein particle stimulus |
| Biological Process |
GO:0007229 |
integrin-mediated signaling pathway |
| Biological Process |
GO:0007517 |
muscle organ development |
| Biological Process |
GO:0045445 |
myoblast differentiation |
| Biological Process |
GO:0007520 |
myoblast fusion |
| Biological Process |
GO:0045906 |
negative regulation of vasoconstriction |
| Biological Process |
GO:0030335 |
positive regulation of cell migration |
| Biological Process |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
| Biological Process |
GO:0031623 |
receptor internalization |
| Biological Process |
GO:0010710 |
regulation of collagen catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.