Search Results

Overview

Uniprot IDQ9GZL7
Protein NameRibosome biogenesis protein WDR12
Gene NameWDR12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
239 NRPRKKQKTEQLGLT

Function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome

Protein Sequence

10 MAQLQTRFYT 20 DNKKYAVDDV 30 PFSIPAASEI 40 ADLSNIINKL 50 LKDKNEFHKH 60 VEFDFLIKGQ 70 FLRMPLDKHM 80 EMENISSEEV 90 VEIEYVEKYT 100 APQPEQCMFH 110 DDWISSIKGA 120 EEWILTGSYD 130 KTSRIWSLEG 140 KSIMTIVGHT 150 DVVKDVAWVK 160 KDSLSCLLLS 170 ASMDQTILLW 180 EWNVERNKVK 190 ALHCCRGHAG 200 SVDSIAVDGS 210 GTKFCSGSWD 220 KMLKIWSTVP 230 TDEEDEMEES 240 TNRPRKKQKT 250 EQLGLTRTPI 260 VTLSGHMEAV 270 SSVLWSDAEE 280 ICSASWDHTI 290 RVWDVESGSL 300 KSTLTGNKVF 310 NCISYSPLCK 320 RLASGSTDRH 330 IRLWDPRTKD 340 GSLVSLSLTS 350 HTGWVTSVKW 360 SPTHEQQLIS 370 GSLDNIVKLW 380 DTRSCKAPLY 390 DLAAHEDKVL 400 SVDWTDTGLL 410 LSGGADNKLY 420 SYRYSPTTSH VGA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0070545 PeBoW complex
Cellular Component GO:0030687 preribosome, large subunit precursor
Molecular Function GO:0043021 ribonucleoprotein complex binding
Biological Process GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0042273 ribosomal large subunit biogenesis
Biological Process GO:0006364 rRNA processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.