Search Results
Overview
| Uniprot ID | Q9GZN8 |
|---|---|
| Protein Name | Adipose-secreted signaling protein |
| Gene Name | ADISSP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 6 | **MAAANKGNKPRVR |
| 9 | AAANKGNKPRVRSIR |
Function
Adipocyte-secreted protein (adipokine) that acts as a key regulator for white adipose tissue (WAT) thermogenesis and glucose homeostasis at least in part through activation of protein kinase A (PKA)
Protein Sequence
10
MAAANKGNKP
20
RVRSIRFAAG
30
HDAEGSHSHV
40
HFDEKLHDSV
50
VMVTQESDSS
60
FLVKVGFLKI
70
LHRYEITFTL
80
PPVHRLSKDV
90
REAPVPSLHL
100
KLLSVVPVPE
110
GYSVKCEYSA
120
HKEGVLKEEI
130
LLACEGGTGT
140
CVRVTVQARV
150
MDRHHGTPML
160
LDGVKCVGAE
170
LEYDSEHSDW
HGFD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0008157 | protein phosphatase 1 binding |
| Biological Process | GO:1990845 | adaptive thermogenesis |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction |
| Biological Process | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.
[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.