Search Results

Overview

Uniprot ID	Q9GZS1
Protein Name	DNA-directed RNA polymerase I subunit RPA49
Gene Name	POLR1E
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
170	SLNRAVAKAAETIID
295	AHRVVKRKSALGPGV

Function

Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates (PubMed:24207024, PubMed:34671025, PubMed:34887565, PubMed:36271492). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:24207024)

Protein Sequence

10 MAAEVLPSAR 20 WQYCGAPDGS 30 QRAVLVQFSN 40 GKLQSPGNMR 50 FTLYENKDST 60 NPRKRNQRIL 70 AAETDRLSYV 80 GNNFGTGALK 90 CNTLCRHFVG 100 ILNKTSGQME 110 VYDAELFNMQ 120 PLFSDVSVES 130 ELALESQTKT 140 YREKMDSCIE 150 AFGTTKQKRA 160 LNTRRMNRVG 170 NESLNRAVAK 180 AAETIIDTKG 190 VTALVSDAIH 200 NDLQDDSLYL 210 PPCYDDAAKP 220 EDVYKFEDLL 230 SPAEYEALQS 240 PSEAFRNVTS 250 EEILKMIEEN 260 SHCTFVIEAL 270 KSLPSDVESR 280 DRQARCIWFL 290 DTLIKFRAHR 300 VVKRKSALGP 310 GVPHIINTKL 320 LKHFTCLTYN 330 NGRLRNLISD 340 SMKAKITAYV 350 IILALHIHDF 360 QIDLTVLQRD 370 LKLSEKRMME 380 IAKAMRLKIS 390 KRRVSVAAGS 400 EEDHKLGTLS 410 LPLPPAQTSD RLAKRRKIT

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0042790	nucleolar large rRNA transcription by RNA polymerase I
Biological Process	GO:0001188	RNA polymerase I preinitiation complex assembly
Cellular Component	GO:0001650	fibrillar center
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005736	RNA polymerase I complex
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0001179	RNA polymerase I general transcription initiation factor binding
Biological Process	GO:0006363	termination of RNA polymerase I transcription
Biological Process	GO:0006362	transcription elongation by RNA polymerase I
Biological Process	GO:0006361	transcription initiation at RNA polymerase I promoter

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.