Search Results
Overview
| Uniprot ID | Q9GZT3 |
|---|---|
| Protein Name | SRA stem-loop-interacting RNA-binding protein, mitochondrial |
| Gene Name | SLIRP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | PQTSDDEKKDF**** |
Function
RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation
Protein Sequence
10
MAASAARGAA
20
ALRRSINQPV
30
AFVRRIPWTA
40
ASSQLKEHFA
50
QFGHVRRCIL
60
PFDKETGFHR
70
GLGWVQFSSE
80
EGLRNALQQE
90
NHIIDGVKVQ
100
VHTRRPKLPQ
TSDDEKKDF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0036126 | sperm flagellum |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0097222 | mitochondrial mRNA polyadenylation |
| Biological Process | GO:1905638 | negative regulation of mitochondrial mRNA catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.