Search Results

Overview

Uniprot ID	Q9GZU2
Protein Name	Paternally-expressed gene 3 protein
Gene Name	PEG3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1132	HQKVHSRKCLVDSRE
1339	YECKDCGKSFIHSTV
1349	IHSTVLTKHKELHLE
1562	GANQADEKYFKCDVC
320	VIMEKFIKDVSRSSK
401	YHFDTDGKGSIHDQK
619	PALNEFQKMYGKEKM
673	FIPGQSLKRRQKTYN
683	QKTYNKEKLCDFTDG
705	SELSEHQKIHSRKNL
720	FEGRGYEKSVIHSGP
761	SNPYENQKIPTKENV
765	ENQKIPTKENVYEAK
772	KENVYEAKSYERSVI
789	LASVEAQKSHSVAGP
871	YISDLNDKRQKIPAR
887	NPCEGGSKNRNYEDS
906	VFRAKPQKSVPGEGS

Function

Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells

Protein Sequence

10 MLPPKHLSAT 20 KPKKSWAPNL 30 YELDSDLTKE 40 PDVIIGEGPT 50 DSEFFHQRFR 60 NLIYVEFVGP 70 RKTLIKLRNL 80 CLDWLQPETR 90 TKEEIIELLV 100 LEQYLTIIPE 110 KLKPWVRAKK 120 PENCEKLVTL 130 LENYKEMYQP 140 EDDNNSDVTS 150 DDDMTRNRRE 160 SSPPHSVHSF 170 SDRDWDRRGR 180 SRDMEPRDRW 190 SHTRNPRSRM 200 PPRDLSLPVV 210 AKTSFEMDRE 220 DDRDSRAYES 230 RSQDAESYQN 240 VVDLAEDRKP 250 HNTIQDNMEN 260 YRKLLSLVQL 270 AEDDGHSHMT 280 QGHSSRSKRS 290 AYPSTSRGLK 300 TMPEAKKSTH 310 RRGICEDESS 320 HGVIMEKFIK 330 DVSRSSKSGR 340 ARESSDRSQR 350 FPRMSDDNWK 360 DISLNKRESV 370 IQQRVYEGNA 380 FRGGFRFNST 390 LVSRKRVLER 400 KRRYHFDTDG 410 KGSIHDQKGC 420 PRKKPFECGS 430 EMRKAMSVSS 440 LSSLSSPSFT 450 ESQPIDFGAM 460 PYVCDECGRS 470 FSVISEFVEH 480 QIMHTRENLY 490 EYGESFIHSV 500 AVSEVQKSQV 510 GGKRFECKDC 520 GETFNKSAAL 530 AEHRKIHARG 540 YLVECKNQEC 550 EEAFMPSPTF 560 SELQKIYGKD 570 KFYECRVCKE 580 TFLHSSALIE 590 HQKIHFGDDK 600 DNEREHERER 610 ERERGETFRP 620 SPALNEFQKM 630 YGKEKMYECK 640 VCGETFLHSS 650 SLKEHQKIHT 660 RGNPFENKGK 670 VCEETFIPGQ 680 SLKRRQKTYN 690 KEKLCDFTDG 700 RDAFMQSSEL 710 SEHQKIHSRK 720 NLFEGRGYEK 730 SVIHSGPFTE 740 SQKSHTITRP 750 LESDEDEKAF 760 TISSNPYENQ 770 KIPTKENVYE 780 AKSYERSVIH 790 SLASVEAQKS 800 HSVAGPSKPK 810 VMAESTIQSF 820 DAINHQRVRA 830 GGNTSEGREY 840 SRSVIHSLVA 850 SKPPRSHNGN 860 ELVESNEKGE 870 SSIYISDLND 880 KRQKIPAREN 890 PCEGGSKNRN 900 YEDSVIQSVF 910 RAKPQKSVPG 920 EGSGEFKKDG 930 EFSVPSSNVR 940 EYQKARAKKK 950 YIEHRSNETS 960 VIHSLPFGEQ 970 TFRPRGMLYE 980 CQECGECFAH 990 SSDLTEHQKI 1000 HDREKPSGSR 1010 NYEWSVIRSL 1020 APTDPQTSYA 1030 QEQYAKEQAR 1040 NKCKDFRQFF 1050 ATSEDLNTNQ 1060 KIYDQEKSHG 1070 EESQGENTDG 1080 EETHSEETHG 1090 QETIEDPVIQ 1100 GSDMEDPQKD 1110 DPDDKIYECE 1120 DCGLGFVDLT 1130 DLTDHQKVHS 1140 RKCLVDSREY 1150 THSVIHTHSI 1160 SEYQRDYTGE 1170 QLYECPKCGE 1180 SFIHSSFLFE 1190 HQRIHEQDQL 1200 YSMKGCDDGF 1210 IALLPMKPRR 1220 NRAAERNPAL 1230 AGSAIRCLLC 1240 GQGFIHSSAL 1250 NEHMRLHRED 1260 DLLEQSQMAE 1270 EAIIPGLALT 1280 EFQRSQTEER 1290 LFECAVCGES 1300 FVNPAELADH 1310 VTVHKNEPYE 1320 YGSSYTHTSF 1330 LTEPLKGAIP 1340 FYECKDCGKS 1350 FIHSTVLTKH 1360 KELHLEEEEE 1370 DEAAAAAAAA 1380 AQEVEANVHV 1390 PQVVLRIQGL 1400 NVEAAEPEVE 1410 AAEPEVEAAE 1420 PEVEAAEPNG 1430 EAEGPDGEAA 1440 EPIGEAGQPN 1450 GEAEQPNGDA 1460 DEPDGAGIED 1470 PEERAEEPEG 1480 KAEEPEGDAD 1490 EPDGVGIEDP 1500 EEGEDQEIQV 1510 EEPYYDCHEC 1520 TETFTSSTAF 1530 SEHLKTHASM 1540 IIFEPANAFG 1550 ECSGYIERAS 1560 TSTGGANQAD 1570 EKYFKCDVCG 1580 QLFNDRLSLA RHQNTHTG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005776	autophagosome
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0010468	regulation of gene expression
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.