Search Results

Overview

Uniprot IDQ9GZU8
Protein NamePSME3-interacting protein
Gene NamePSME3IP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
12 DDGNLIIKKRFVSEA
121 EYRNNLKKVGISQEN
135 NKKEVEKKLTVKPIE
139 VEKKLTVKPIETKNK
144 TVKPIETKNKFSQAK
146 KPIETKNKFSQAKLL
151 KNKFSQAKLLAGAVK
158 KLLAGAVKHKSSESG
160 LAGAVKHKSSESGNS
169 SESGNSVKRLKPDPE
74 QEYEEQFKFKNMVRG

Function

Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus

Protein Sequence

10 MDGGDDGNLI 20 IKKRFVSEAE 30 LDERRKRRQE 40 EWEKVRKPED 50 PEECPEEVYD 60 PRSLYERLQE 70 QKDRKQQEYE 80 EQFKFKNMVR 90 GLDEDETNFL 100 DEVSRQQELI 110 EKQRREEELK 120 ELKEYRNNLK 130 KVGISQENKK 140 EVEKKLTVKP 150 IETKNKFSQA 160 KLLAGAVKHK 170 SSESGNSVKR 180 LKPDPEPDDK 190 NQEPSSCKSL 200 GNTSLSGPSI 210 HCPSAAVCIG 220 ILPGLGAYSG 230 SSDSESSSDS 240 EGTINATGKI 250 VSSIFRTNTF LEAP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:1901799 negative regulation of proteasomal protein catabolic process
Biological Process GO:0032091 negative regulation of protein binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.