Search Results

Overview

Uniprot ID	Q9GZV4
Protein Name	Eukaryotic translation initiation factor 5A-2
Gene Name	EIF5A2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
39	VLKGRPCKIVEMSTS
67	GIDIFTGKKYEDICP

Function

Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:14622290). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity)

Protein Sequence

10 MADEIDFTTG 20 DAGASSTYPM 30 QCSALRKNGF 40 VVLKGRPCKI 50 VEMSTSKTGK 60 HGHAKVHLVG 70 IDIFTGKKYE 80 DICPSTHNMD 90 VPNIKRNDYQ 100 LICIQDGYLS 110 LLTETGEVRE 120 DLKLPEGELG 130 KEIEGKYNAG 140 EDVQVSVMCA 150 MSEEYAVAIK PCK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0043022	ribosome binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003746	translation elongation factor activity
Biological Process	GO:0007283	spermatogenesis
Biological Process	GO:0006414	translational elongation

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.