Search Results
Overview
| Uniprot ID | Q9GZV7 |
|---|---|
| Protein Name | Hyaluronan and proteoglycan link protein 2 |
| Gene Name | HAPLN2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 167 | QFNYYEAKQACEEQD |
| 72 | SYKVRWSKVEPGELR |
Function
Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity)
Protein Sequence
10
MPGWLTLPTL
20
CRFLLWAFTI
30
FHKAQGDPAS
40
HPGPHYLLPP
50
IHEVIHSHRG
60
ATATLPCVLG
70
TTPPSYKVRW
80
SKVEPGELRE
90
TLILITNGLH
100
ARGYGPLGGR
110
ARMRRGHRLD
120
ASLVIAGVRL
130
EDEGRYRCEL
140
INGIEDESVA
150
LTLSLEGVVF
160
PYQPSRGRYQ
170
FNYYEAKQAC
180
EEQDGRLATY
190
SQLYQAWTEG
200
LDWCNAGWLL
210
EGSVRYPVLT
220
ARAPCGGRGR
230
PGIRSYGPRD
240
RMRDRYDAFC
250
FTSALAGQVF
260
FVPGRLTLSE
270
AHAACRRRGA
280
VVAKVGHLYA
290
AWKFSGLDQC
300
DGGWLADGSV
310
RFPITTPRPR
320
CGGLPDPGVR
330
SFGFPRPQQA
340
AYGTYCYAEN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0140150 | gel phase of interstitial matrix |
| Cellular Component | GO:0033268 | node of Ranvier |
| Cellular Component | GO:0072534 | perineuronal net |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0005540 | hyaluronic acid binding |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0001501 | skeletal system development |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.