Overview
| Uniprot ID | Q9GZX6 |
|---|
| Protein Name | Interleukin-22 |
|---|
| Gene Name | IL22 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 6 |
**MAALQKSVSSFLM |
Function
Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed:17204547). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed:17204547). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB (PubMed:10875937, PubMed:18599299). Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways (PubMed:25793261, PubMed:31311100). Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (By similarity). Promotes epithelial cell spreading (By similarity)
Protein Sequence
10
MAALQKSVSS
20
FLMGTLATSC
30
LLLLALLVQG
40
GAAAPISSHC
50
RLDKSNFQQP
60
YITNRTFMLA
70
KEASLADNNT
80
DVRLIGEKLF
90
HGVSMSERCY
100
LMKQVLNFTL
110
EEVLFPQSDR
120
FQPYMQEVVP
130
FLARLSNRLS
140
TCHIEGDDLH
150
IQRNVQKLKD
160
TVKKLGESGE
170
IKAIGELDLL
FMSLRNACI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Molecular Function |
GO:0005125 |
cytokine activity |
| Molecular Function |
GO:0045518 |
interleukin-22 receptor binding |
| Biological Process |
GO:0006953 |
acute-phase response |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0050728 |
negative regulation of inflammatory response |
| Biological Process |
GO:0051384 |
response to glucocorticoid |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.