Search Results
Overview
| Uniprot ID | Q9H000 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase makorin-2 |
| Gene Name | MKRN2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 362 | AEPEKPRKQLSSQGT |
Function
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity)
Protein Sequence
10
MSTKQITCRY
20
FMHGVCREGS
30
QCLFSHDLAN
40
SKPSTICKYY
50
QKGYCAYGTR
60
CRYDHTRPSA
70
AAGGAVGTMA
80
HSVPSPAFHS
90
PHPPSEVTAS
100
IVKTNSHEPG
110
KREKRTLVLR
120
DRNLSGMAER
130
KTQPSMVSNP
140
GSCSDPQPSP
150
EMKPHSYLDA
160
IRSGLDDVEA
170
SSSYSNEQQL
180
CPYAAAGECR
190
FGDACVYLHG
200
EVCEICRLQV
210
LHPFDPEQRK
220
AHEKICMLTF
230
EHEMEKAFAF
240
QASQDKVCSI
250
CMEVILEKAS
260
ASERRFGILS
270
NCNHTYCLSC
280
IRQWRCAKQF
290
ENPIIKSCPE
300
CRVISEFVIP
310
SVYWVEDQNK
320
KNELIEAFKQ
330
GMGKKACKYF
340
EQGKGTCPFG
350
SKCLYRHAYP
360
DGRLAEPEKP
370
RKQLSSQGTV
380
RFFNSVRLWD
390
FIENRESRHV
400
PNNEDVDMTE
410
LGDLFMHLSG
VESSEP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus |
| Biological Process | GO:1901223 | negative regulation of non-canonical NF-kappaB signal transduction |
| Biological Process | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0000209 | protein polyubiquitination |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.