Search Results
Overview
| Uniprot ID | Q9H008 |
|---|---|
| Protein Name | Phospholysine phosphohistidine inorganic pyrophosphate phosphatase |
| Gene Name | LHPP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 183 | LEYACGIKAEVVGKP |
Function
Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity)
Protein Sequence
10
MAPWGKRLAG
20
VRGVLLDISG
30
VLYDSGAGGG
40
TAIAGSVEAV
50
ARLKRSRLKV
60
RFCTNESQKS
70
RAELVGQLQR
80
LGFDISEQEV
90
TAPAPAACQI
100
LKEQGLRPYL
110
LIHDGVRSEF
120
DQIDTSNPNC
130
VVIADAGESF
140
SYQNMNNAFQ
150
VLMELEKPVL
160
ISLGKGRYYK
170
ETSGLMLDVG
180
PYMKALEYAC
190
GIKAEVVGKP
200
SPEFFKSALQ
210
AIGVEAHQAV
220
MIGDDIVGDV
230
GGAQRCGMRA
240
LQVRTGKFRP
250
SDEHHPEVKA
260
DGYVDNLAEA
270
VDLLLQHADK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004427 | inorganic diphosphate phosphatase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0016791 | phosphatase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006796 | phosphate-containing compound metabolic process |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.