Search Results

Overview

Uniprot ID	Q9H074
Protein Name	Polyadenylate-binding protein-interacting protein 1
Gene Name	PAIP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
49	RHQPPQPKAPGFLQP

Function

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain

Protein Sequence

10 MSDGFDRAPG 20 AGRGRSRGLG 30 RGGGGPEGGG 40 FPNGAGPAER 50 ARHQPPQPKA 60 PGFLQPPPLR 70 QPRTTPPPGA 80 QCEVPASPQR 90 PSRPGALPEQ 100 TRPLRAPPSS 110 QDKIPQQNSE 120 SAMAKPQVVV 130 APVLMSKLSV 140 NAPEFYPSGY 150 SSSYTESYED 160 GCEDYPTLSE 170 YVQDFLNHLT 180 EQPGSFETEI 190 EQFAETLNGC 200 VTTDDALQEL 210 VELIYQQATS 220 IPNFSYMGAR 230 LCNYLSHHLT 240 ISPQSGNFRQ 250 LLLQRCRTEY 260 EVKDQAAKGD 270 EVTRKRFHAF 280 VLFLGELYLN 290 LEIKGTNGQV 300 TRADILQVGL 310 RELLNALFSN 320 PMDDNLICAV 330 KLLKLTGSVL 340 EDAWKEKGKM 350 DMEEIIQRIE 360 NVVLDANCSR 370 DVKQMLLKLV 380 ELRSSNWGRV 390 HATSTYREAT 400 PENDPNYFMN 410 EPTFYTSDGV 420 PFTAADPDYQ 430 EKYQELLERE 440 DFFPDYEENG 450 TDLSGAGDPY 460 LDDIDDEMDP 470 EIEEAYEKFC LESERKRKQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0008494	translation activator activity
Biological Process	GO:0070934	CRD-mediated mRNA stabilization
Biological Process	GO:0044794	host-mediated activation of viral process
Biological Process	GO:0048255	mRNA stabilization
Biological Process	GO:1900152	negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Process	GO:2000767	positive regulation of cytoplasmic translation
Biological Process	GO:0006446	regulation of translational initiation
Biological Process	GO:0006413	translational initiation
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0003723	RNA binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.