Search Results
Overview
| Uniprot ID | Q9H0B6 |
|---|---|
| Protein Name | Kinesin light chain 2 |
| Gene Name | KLC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 480 | DCASRNRKQGLDPAS |
| 563 | SSEMLVKKLQGGTPQ |
Function
Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677)
Protein Sequence
10
MAMMVFPREE
20
KLSQDEIVLG
30
TKAVIQGLET
40
LRGEHRALLA
50
PLVAPEAGEA
60
EPGSQERCIL
70
LRRSLEAIEL
80
GLGEAQVILA
90
LSSHLGAVES
100
EKQKLRAQVR
110
RLVQENQWLR
120
EELAGTQQKL
130
QRSEQAVAQL
140
EEEKQHLLFM
150
SQIRKLDEDA
160
SPNEEKGDVP
170
KDTLDDLFPN
180
EDEQSPAPSP
190
GGGDVSGQHG
200
GYEIPARLRT
210
LHNLVIQYAS
220
QGRYEVAVPL
230
CKQALEDLEK
240
TSGHDHPDVA
250
TMLNILALVY
260
RDQNKYKEAA
270
HLLNDALAIR
280
EKTLGKDHPA
290
VAATLNNLAV
300
LYGKRGKYKE
310
AEPLCKRALE
320
IREKVLGKFH
330
PDVAKQLSNL
340
ALLCQNQGKA
350
EEVEYYYRRA
360
LEIYATRLGP
370
DDPNVAKTKN
380
NLASCYLKQG
390
KYQDAETLYK
400
EILTRAHEKE
410
FGSVNGDNKP
420
IWMHAEEREE
430
SKDKRRDSAP
440
YGEYGSWYKA
450
CKVDSPTVNT
460
TLRSLGALYR
470
RQGKLEAAHT
480
LEDCASRNRK
490
QGLDPASQTK
500
VVELLKDGSG
510
RRGDRRSSRD
520
MAGGAGPRSE
530
SDLEDVGPTA
540
EWNGDGSGSL
550
RRSGSFGKLR
560
DALRRSSEML
570
VKKLQGGTPQ
580
EPPNPRMKRA
590
SSLNFLNKSV
600
EEPTQPGGTG
610
LSDSRTLSSS
620
SMDLSRRSSL
VG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005871 | kinesin complex |
| Cellular Component | GO:0016938 | kinesin I complex |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0019894 | kinesin binding |
| Biological Process | GO:0032418 | lysosome localization |
| Biological Process | GO:0007018 | microtubule-based movement |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.