Search Results

Overview

Uniprot IDQ9H0C8
Protein NameIntegrin-linked kinase-associated serine/threonine phosphatase 2C
Gene NameILKAP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
204 HTDEEFLKQASSQKP
273 EERMRIQKAGGNVRD
299 SIGDGQYKRCGVTSV
99 LVEKKVCKASSVIFG

Function

Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation

Protein Sequence

10 MDLFGDLPEP 20 ERSPRPAAGK 30 EAQKGPLLFD 40 DLPPASSTDS 50 GSGGPLLFDD 60 LPPASSGDSG 70 SLATSISQMV 80 KTEGKGAKRK 90 TSEEEKNGSE 100 ELVEKKVCKA 110 SSVIFGLKGY 120 VAERKGEREE 130 MQDAHVILND 140 ITEECRPPSS 150 LITRVSYFAV 160 FDGHGGIRAS 170 KFAAQNLHQN 180 LIRKFPKGDV 190 ISVEKTVKRC 200 LLDTFKHTDE 210 EFLKQASSQK 220 PAWKDGSTAT 230 CVLAVDNILY 240 IANLGDSRAI 250 LCRYNEESQK 260 HAALSLSKEH 270 NPTQYEERMR 280 IQKAGGNVRD 290 GRVLGVLEVS 300 RSIGDGQYKR 310 CGVTSVPDIR 320 RCQLTPNDRF 330 ILLACDGLFK 340 VFTPEEAVNF 350 ILSCLEDEKI 360 QTREGKSAAD 370 ARYEAACNRL 380 ANKAVQRGSA 390 DNVTVMVVRI GH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004722 protein serine/threonine phosphatase activity
Biological Process GO:0007165 signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.