Search Results

Overview

Uniprot IDQ9H0D6
Protein Name5'-3' exoribonuclease 2
Gene NameXRN2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
937 GYPREGRKYPLPPPS

Function

Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224)

Protein Sequence

10 MGVPAFFRWL 20 SRKYPSIIVN 30 CVEEKPKECN 40 GVKIPVDASK 50 PNPNDVEFDN 60 LYLDMNGIIH 70 PCTHPEDKPA 80 PKNEDEMMVA 90 IFEYIDRLFS 100 IVRPRRLLYM 110 AIDGVAPRAK 120 MNQQRSRRFR 130 ASKEGMEAAV 140 EKQRVREEIL 150 AKGGFLPPEE 160 IKERFDSNCI 170 TPGTEFMDNL 180 AKCLRYYIAD 190 RLNNDPGWKN 200 LTVILSDASA 210 PGEGEHKIMD 220 YIRRQRAQPN 230 HDPNTHHCLC 240 GADADLIMLG 250 LATHEPNFTI 260 IREEFKPNKP 270 KPCGLCNQFG 280 HEVKDCEGLP 290 REKKGKHDEL 300 ADSLPCAEGE 310 FIFLRLNVLR 320 EYLERELTMA 330 SLPFTFDVER 340 SIDDWVFMCF 350 FVGNDFLPHL 360 PSLEIRENAI 370 DRLVNIYKNV 380 VHKTGGYLTE 390 SGYVNLQRVQ 400 MIMLAVGEVE 410 DSIFKKRKDD 420 EDSFRRRQKE 430 KRKRMKRDQP 440 AFTPSGILTP 450 HALGSRNSPG 460 SQVASNPRQA 470 AYEMRMQNNS 480 SPSISPNTSF 490 TSDGSPSPLG 500 GIKRKAEDSD 510 SEPEPEDNVR 520 LWEAGWKQRY 530 YKNKFDVDAA 540 DEKFRRKVVQ 550 SYVEGLCWVL 560 RYYYQGCASW 570 KWYYPFHYAP 580 FASDFEGIAD 590 MPSDFEKGTK 600 PFKPLEQLMG 610 VFPAASGNFL 620 PPSWRKLMSD 630 PDSSIIDFYP 640 EDFAIDLNGK 650 KYAWQGVALL 660 PFVDERRLRA 670 ALEEVYPDLT 680 PEETRRNSLG 690 GDVLFVGKHH 700 PLHDFILELY 710 QTGSTEPVEV 720 PPELCHGIQG 730 KFSLDEEAIL 740 PDQIVCSPVP 750 MLRDLTQNTV 760 VSINFKDPQF 770 AEDYIFKAVM 780 LPGARKPAAV 790 LKPSDWEKSS 800 NGRQWKPQLG 810 FNRDRRPVHL 820 DQAAFRTLGH 830 VMPRGSGTGI 840 YSNAAPPPVT 850 YQGNLYRPLL 860 RGQAQIPKLM 870 SNMRPQDSWR 880 GPPPLFQQQR 890 FDRGVGAEPL 900 LPWNRMLQTQ 910 NAAFQPNQYQ 920 MLAGPGGYPP 930 RRDDRGGRQG 940 YPREGRKYPL 950 PPPSGRYNWN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0008409 5'-3' exonuclease activity
Molecular Function GO:0004534 5'-3' RNA exonuclease activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0004518 nuclease activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0001147 transcription termination site sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0021766 hippocampus development
Biological Process GO:0006397 mRNA processing
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0000956 nuclear-transcribed mRNA catabolic process
Biological Process GO:0060041 retina development in camera-type eye
Biological Process GO:0006401 RNA catabolic process
Biological Process GO:0016070 RNA metabolic process
Biological Process GO:0006396 RNA processing
Biological Process GO:0006364 rRNA processing
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0006369 termination of RNA polymerase II transcription

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.