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Overview

Uniprot IDQ9H0E3
Protein NameHistone deacetylase complex subunit SAP130
Gene NameSAP130
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
869 TAKSLLVKAEKRKSP
981 EGIIPKKKAATDDDL

Function

Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes

Protein Sequence

10 MGPPRHPQAG 20 EIEAGGAGGG 30 RRLQVEMSSQ 40 QFPRLGAPST 50 GLSQAPSQIA 60 NSGSAGLINP 70 AATVNDESGR 80 DSEVSAREHM 90 SSSSSLQSRE 100 EKQEPVVVRP 110 YPQVQMLSTH 120 HAVASATPVA 130 VTAPPAHLTP 140 AVPLSFSEGL 150 MKPPPKPTMP 160 SRPIAPAPPS 170 TLSLPPKVPG 180 QVTVTMESSI 190 PQASAIPVAT 200 ISGQQGHPSN 210 LHHIMTTNVQ 220 MSIIRSNAPG 230 PPLHIGASHL 240 PRGAAAAAVM 250 SSSKVTTVLR 260 PTSQLPNAAT 270 AQPAVQHIIH 280 QPIQSRPPVT 290 TSNAIPPAVV 300 ATVSATRAQS 310 PVITTTAAHA 320 TDSALSRPTL 330 SIQHPPSAAI 340 SIQRPAQSRD 350 VTTRITLPSH 360 PALGTPKQQL 370 HTMAQKTIFS 380 TGTPVAAATV 390 APILATNTIP 400 SATTAGSVSH 410 TQAPTSTIVT 420 MTVPSHSSHA 430 TAVTTSNIPV 440 AKVVPQQITH 450 TSPRIQPDYP 460 AERSSLIPIS 470 GHRASPNPVA 480 METRSDNRPS 490 VPVQFQYFLP 500 TYPPSAYPLA 510 AHTYTPITSS 520 VSTIRQYPVS 530 AQAPNSAITA 540 QTGVGVASTV 550 HLNPMQLMTV 560 DASHARHIQG 570 IQPAPISTQG 580 IQPAPIGTPG 590 IQPAPLGTQG 600 IHSATPINTQ 610 GLQPAPMGTQ 620 QPQPEGKTSA 630 VVLADGATIV 640 ANPISNPFSA 650 APAATTVVQT 660 HSQSASTNAP 670 AQGSSPRPSI 680 LRKKPATDGA 690 KPKSEIHVSM 700 ATPVTVSMET 710 VSNQNNDQPT 720 IAVPPTAQQP 730 PPTIPTMIAA 740 ASPPSQPAVA 750 LSTIPGAVPI 760 TPPITTIAAA 770 PPPSVTVGGS 780 LSSVLGPPVP 790 EIKVKEEVEP 800 MDIMRPVSAV 810 PPLATNTVSP 820 SLALLANNLS 830 MPTSDLPPGA 840 SPRKKPRKQQ 850 HVISTEEGDM 860 METNSTDDEK 870 STAKSLLVKA 880 EKRKSPPKEY 890 IDEEGVRYVP 900 VRPRPPITLL 910 RHYRNPWKAA 920 YHHFQRYSDV 930 RVKEEKKAML 940 QEIANQKGVS 950 CRAQGWKVHL 960 CAAQLLQLTN 970 LEHDVYERLT 980 NLQEGIIPKK 990 KAATDDDLHR 1000 INELIQGNMQ 1010 RCKLVMDQIS 1020 EARDSMLKVL 1030 DHKDRVLKLL 1040 NKNGTVKKVS KLKRKEKV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005634 nucleus
Cellular Component GO:0070822 Sin3-type complex
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:1902455 negative regulation of stem cell population maintenance
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:1902459 positive regulation of stem cell population maintenance

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.