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Overview

Uniprot ID	Q9H0E9
Protein Name	Bromodomain-containing protein 8
Gene Name	BRD8
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
9	ATGTGKHKLLSTGPT

Function

May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome

Protein Sequence

10 MATGTGKHKL 20 LSTGPTEPWS 30 IREKLCLASS 40 VMRSGDQNWV 50 SVSRAIKPFA 60 EPGRPPDWFS 70 QKHCASQYSE 80 LLETTETPKR 90 KRGEKGEVVE 100 TVEDVIVRKL 110 TAERVEELKK 120 VIKETQERYR 130 RLKRDAELIQ 140 AGHMDSRLDE 150 LCNDIATKKK 160 LEEEEAEVKR 170 KATDAAYQAR 180 QAVKTPPRRL 190 PTVMVRSPID 200 SASPGGDYPL 210 GDLTPTTMEE 220 ATSGVNESEM 230 AVASGHLNST 240 GVLLEVGGVL 250 PMIHGGEIQQ 260 TPNTVAASPA 270 ASGAPTLSRL 280 LEAGPTQFTT 290 PLASFTTVAS 300 EPPVKLVPPP 310 VESVSQATIV 320 MMPALPAPSS 330 APAVSTTESV 340 APVSQPDNCV 350 PMEAVGDPHT 360 VTVSMDSSEI 370 SMIINSIKEE 380 CFRSGVAEAP 390 VGSKAPSIDG 400 KEELDLAEKM 410 DIAVSYTGEE 420 LDFETVGDII 430 AIIEDKVDDH 440 PEVLDVAAVE 450 AALSFCEEND 460 DPQSLPGPWE 470 HPIQQERDKP 480 VPLPAPEMTV 490 KQERLDFEET 500 ENKGIHELVD 510 IREPSAEIKV 520 EPAEPEPVIS 530 GAEIVAGVVP 540 ATSMEPPELR 550 SQDLDEELGS 560 TAAGEIVEAD 570 VAIGKGDETP 580 LTNVKTEASP 590 ESMLSPSHGS 600 NPIEDPLEAE 610 TQHKFEMSDS 620 LKEESGTIFG 630 SQIKDAPGED 640 EEEDGVSEAA 650 SLEEPKEEDQ 660 GEGYLSEMDN 670 EPPVSESDDG 680 FSIHNATLQS 690 HTLADSIPSS 700 PASSQFSVCS 710 EDQEAIQAQK 720 IWKKAIMLVW 730 RAAANHRYAN 740 VFLQPVTDDI 750 APGYHSIVQR 760 PMDLSTIKKN 770 IENGLIRSTA 780 EFQRDIMLMF 790 QNAVMYNSSD 800 HDVYHMAVEM 810 QRDVLEQIQQ 820 FLATQLIMQT 830 SESGISAKSL 840 RGRDSTRKQD 850 ASEKDSVPMG 860 SPAFLLSLFM 870 GHEWVWLDSE 880 QDHPNDSELS 890 NDCRSLFSSW 900 DSSLDLDVGN 910 WRETEDPEAE 920 ELEESSPERE 930 PSELLVGDGG 940 SEESQEAARK 950 ASHQNLLHFL 960 SEVAYLMEPL 970 CISSNESSEG 980 CCPPSGTRQE 990 GREIKASEGE 1000 RELCRETEEL 1010 SAKGDPLVAE 1020 KPLGENGKPE 1030 VASAPSVICT 1040 VQGLLTESEE 1050 GEAQQESKGE 1060 DQGEVYVSEM 1070 EDQPPSGECD 1080 DAFNIKETPL 1090 VDTLFSHATS 1100 SKLTDLSQDD 1110 PVQDHLLFKK 1120 TLLPVWKMIA 1130 SHRFSSPFLK 1140 PVSERQAPGY 1150 KDVVKRPMDL 1160 TSLKRNLSKG 1170 RIRTMAQFLR 1180 DLMLMFQNAV 1190 MYNDSDHHVY 1200 HMAVEMRQEV 1210 LEQIQVLNIW 1220 LDKRKGSSSL 1230 EGEPANPVDD GKPVF

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus
Cellular Component	GO:0035267	NuA4 histone acetyltransferase complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000812	Swr1 complex
Molecular Function	GO:0046966	nuclear thyroid hormone receptor binding
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0007166	cell surface receptor signaling pathway
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0042981	regulation of apoptotic process
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:2000779	regulation of double-strand break repair

Reference

[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.